• 靶点-Target： GSK3β
• MW(Calculated)： 47kD
• 宿主物种-Host Species： Mouse
• 修饰-Modification： Unmodified
• 推荐稀释比： WB 1:500-1:2000;IHC 1:200-1:1000;IF 1:200-1:1000;Flow Cyt 1:200-1:400;ELISA 1:10000;Not yet tested in other applications.
• 组成： Liquid in PBS containing 50% glycerol， 0.5% BSA and 0.02% sodium azide.
• 纯化工艺： Affinity purification
• 储存： -15°C to -25°C/1 year(Do not lower than -25°C)
• 克隆性： Monoclonal
• 免疫原： Purified recombinant fragment of human GSK3β expressed in E. Coli.
• 特异性： GSK3β Monoclonal Antibody detects endogenous levels of GSK3β protein.
• 基因名称： GSK3B
• 蛋白名称： Glycogen synthase kinase-3 beta
• Organism-1： Human
• 基因ID-1： 2942
• SwissProt-1： P49841
• Organism-2： Mouse
• 基因ID-2： 56637
• SwissProt-2： Q9WV60
• Organism-3： Rat
• 基因ID-3： 84027
• SwissProt-3： P18266
• 背景： The protein encoded by this gene is a serine-threonine kinase， belonging to the glycogen synthase kinase subfamily. It is involved in energy metabolism， neuronal cell development， and body pattern formation. Polymorphisms in this gene have been implicated in modifying risk of Parkinson disease， and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq， Sep 2009]，
• 细胞定位： Cytoplasm . Nucleus . Cell membrane . The phosphorylated form shows localization to cytoplasm and cell membrane (PubMed:20937854). The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosphorylated form to the cell membrane (PubMed:20937854). .

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