• 靶点-Target： Csk
• MW(Calculated)： 51kD
• 宿主物种-Host Species： Mouse
• 修饰-Modification： Unmodified
• 推荐稀释比： WB 1:500-1:2000;IF 1:200-1:1000;Flow Cyt 1:200-1:400;ELISA 1:10000;Not yet tested in other applications.
• 组成： Liquid in PBS containing 50% glycerol， 0.5% BSA and 0.02% sodium azide.
• 纯化工艺： Affinity purification
• 储存： -15°C to -25°C/1 year(Do not lower than -25°C)
• 克隆性： Monoclonal
• 免疫原： Purified recombinant fragment of human Csk expressed in E. Coli.
• 特异性： Csk Monoclonal Antibody detects endogenous levels of Csk protein.
• 基因名称： CSK
• 蛋白名称： Tyrosine-protein kinase CSK
• Organism-1： Human
• 基因ID-1： 1445
• SwissProt-1： P41240
• Organism-2： Mouse
• 基因ID-2： 12988
• SwissProt-2： P41241
• Organism-3： Rat
• 基因ID-3： 315707
• SwissProt-3： P32577
• 背景： catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.，function:Specifically phosphorylates ‘Tyr-504‘ on LCK， which acts as a negative regulatory site. Can also act on the LYN and FYN kinases.，PTM:Autophosphorylation of Tyr-304 occurs only at abnormally high CSK concentrations in vitro.，similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.，similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. CSK subfamily.，similarity:Contains 1 protein kinase domain.，similarity:Contains 1 SH2 domain.，similarity:Contains 1 SH3 domain.，subcellular location:Mainly cytoplasmic， also present in lipid rafts.，subunit:Interacts with PTPN8 (By similarity). Interacts with phosphorylated SIT1， PAG1， LIME1 and TGFB1I1.，tissue specificity:Expressed in lung and macrophages.，
• 细胞定位： Cytoplasm . Cell membrane . Mainly cytoplasmic， also present in lipid rafts. .

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