• 靶点-Target： HIF-1α
• MW(Calculated)： 93kD
• 宿主物种-Host Species： Mouse
• 修饰-Modification： Unmodified
• 推荐稀释比： WB 1:500-1:2000;IHC 1:200-1:1000;IF 1:200-1:1000;ELISA 1:10000;Not yet tested in other applications.
• 组成： Liquid in PBS containing 50% glycerol， 0.5% BSA and 0.02% sodium azide.
• 纯化工艺： Affinity purification
• 储存： -15°C to -25°C/1 year(Do not lower than -25°C)
• 克隆性： Monoclonal
• 免疫原： Purified recombinant fragment of human HIF-1α expressed in E. Coli.
• 特异性： HIF-1α Monoclonal Antibody detects endogenous levels of HIF-1α protein.
• 基因名称： HIF1A
• 蛋白名称： Hypoxia-inducible factor 1-alpha
• Organism-1： Human
• 基因ID-1： 3091
• SwissProt-1： Q16665
• Organism-2： Mouse
• 基因ID-2： 15251
• SwissProt-2： Q61221
• 背景： hypoxia inducible factor 1 alpha subunit(HIF1A) Homo sapiens This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1)， which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes， including those involved in energy metabolism， angiogenesis， apoptosis， and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization， tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq， Jul 2011]，
• 细胞定位： Cytoplasm . Nucleus . Nucleus speckle . Colocalizes with HIF3A in the nucleus and speckles (By similarity). Cytoplasmic in normoxia， nuclear translocation in response to hypoxia (PubMed:9822602). .

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