• 靶点-Target： Caspase-8
• MW(Observed)： 47kD，55kD
• 宿主物种-Host Species： Rabbit
• 同种型-Isotype： IgG
• 修饰-Modification： Unmodified
• 推荐稀释比： WB 1:500-2000;IF 1:50-300;IHC 1:50-300
• 组成： Liquid in PBS containing 50% glycerol， 0.5% BSA and 0.02% sodium azide.
• 纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• 储存： -15°C to -25°C/1 year(Do not lower than -25°C)
• 浓度： 1 mg/ml
• 克隆性： Polyclonal
• 免疫原： The antiserum was produced against synthesized peptide derived from human Caspase 8. AA range:335-384
• 特异性： Cleaved-Caspase-8 (D384) Polyclonal Antibody detects endogenous levels of fragment of activated Caspase-8 protein resulting from cleavage adjacent to D384.
• 基因名称： CASP8
• 蛋白名称： Caspase8
• Organism-1： Human
• 基因ID-1： 841
• SwissProt-1： Q14790
• Organism-2： Mouse
• SwissProt-2： O89110
• 背景： This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain， a large protease subunit， and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls， which implicated the role in neurodegenerative diseases. Many alt
• 细胞定位： Cytoplasm . Nucleus .

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