• 靶点-Target： Caspase-3
• MW(Observed)： 17kD，34kD
• 宿主物种-Host Species： Rabbit
• 同种型-Isotype： IgG
• 修饰-Modification： Unmodified
• 推荐稀释比： WB 1:500-2000;IHC 1:50-300;IF 1:50-300
• 组成： Liquid in PBS containing 50% glycerol， 0.5% BSA and 0.02% sodium azide.
• 纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• 储存： -15°C to -25°C/1 year(Do not lower than -25°C)
• 浓度： 1 mg/ml
• 克隆性： Polyclonal
• 免疫原： The antiserum was produced against synthesized peptide derived from human Caspase 3. AA range:126-175
• 特异性： Cleaved-Caspase-3 p17 (D175) Polyclonal Antibody detects endogenous levels of fragment of activated Caspase-3 p17 protein resulting from cleavage adjacent to D175.
• 基因名称： CASP3
• 蛋白名称： Caspase3
• Organism-1： Human
• 基因ID-1： 836
• SwissProt-1： P42574
• Organism-2： Mouse
• 基因ID-2： 12367
• SwissProt-2： P70677
• Organism-3： Rat
• 基因ID-3： 25402
• SwissProt-3： P55213
• 背景： This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits， large and small， that dimerize to form the active enzyme. This protein cleaves and activates caspases 6， 7 and 9， and the protein itself is processed by caspases 8， 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein， which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. [provided by RefSeq， Jul 2008]，
• 细胞定位： Cytoplasm.

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