• 靶点-Target： WDR79
• MW(Calculated)： 59kD
• 宿主物种-Host Species： Mouse
• 修饰-Modification： Unmodified
• 推荐稀释比： WB 1:1000-1:2000;Not yet tested in other applications.
• 组成： Liquid in PBS containing 50% glycerol， 0.5% BSA and 0.02% sodium azide.
• 纯化工艺： Affinity purification
• 储存： -15°C to -25°C/1 year(Do not lower than -25°C)
• 克隆性： Monoclonal
• 免疫原： Purified recombinant human WDR79 protein fragments expressed in E.coli.
• 特异性： WDR79 Monoclonal Antibody detects endogenous levels of WDR79 protein.
• 基因名称： WRAP53
• 蛋白名称： Telomerase Cajal body protein 1
• Organism-1： Human
• 基因ID-1： 55135
• SwissProt-1： Q9BUR4
• Organism-2： Mouse
• 基因ID-2： 216853
• SwissProt-2： Q8VC51
• Organism-3： Rat
• 基因ID-3： 287432
• SwissProt-3： Q5XII5
• 背景： This gene encodes an essential component of the telomerase holoenzyme complex， a ribonucleoprotein complex required for telomere synthesis. This protein is enriched in Cajal bodies， nuclear sites of RNP processing that are important for telomerase function. It interacts with dyskerin， TERT and TERC， other components of active telomerase， and with small Cajal body RNAs (scaRNAs)， which are involved in modifying splicing RNAs. This mRNA also functions as a p53 antisense transcript， that regulates endogenous p53 mRNA levels and further induction of p53 protein by targeting the 5' untranslated region of p53 mRNA. Alternatively spliced transcript variants which differ only in the 5' UTR have been found for this gene. [provided by RefSeq， Mar 2011]，
• 细胞定位： Nucleus， Cajal body . Chromosome， telomere . Chromosome . Released from telomerase RNA template component (TERC) in mitotic cells coincident with delocalization from Cajal bodies (PubMed:26170453). In response to DNA damage， localizes to sites of DNA double-strand breaks following phosphorylation by ATM (PubMed:26734725， PubMed:27715493). .

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