• 靶点-Target： PRMT6
• MW(Calculated)： 42kD
• 宿主物种-Host Species： Mouse
• 修饰-Modification： Unmodified
• 推荐稀释比： WB 1:1000-1:2000;IHC 1:500-1:1000;IF 1:100-1:500;Not yet tested in other applications.
• 组成： Liquid in PBS containing 50% glycerol， 0.5% BSA and 0.02% sodium azide.
• 纯化工艺： Affinity purification
• 储存： -15°C to -25°C/1 year(Do not lower than -25°C)
• 克隆性： Monoclonal
• 免疫原： Purified recombinant human PRMT6 protein fragments expressed in E.coli.
• 特异性： PRMT6 Monoclonal Antibody detects endogenous levels of PRMT6 protein.
• 基因名称： PRMT6
• 蛋白名称： Protein arginine N-methyltransferase 6
• Organism-1： Human
• 基因ID-1： 55170
• SwissProt-1： Q96LA8
• Organism-2： Mouse
• 基因ID-2： 99890
• SwissProt-2： Q6NZB1
• 背景： The protein encoded by this gene belongs to the arginine N-methyltransferase family， which catalyze the sequential transfer of methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins， to form methylated arginine derivatives and S-adenosyl-L-homocysteine. This protein can catalyze both， the formation of omega-N monomethylarginine and asymmetrical dimethylarginine， with a strong preference for the latter. It specifically mediates the asymmetric dimethylation of Arg2 of histone H3， and the methylated form represents a specific tag for epigenetic transcriptional repression. This protein also forms a complex with， and methylates DNA polymerase beta， resulting in stimulation of polymerase activity by enhancing DNA binding and processivity. [provided by RefSeq， Sep 2011]，
• 细胞定位： Nucleus .

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