• 靶点-Target： PP2B-Aα
• MW(Calculated)： 59kD
• 宿主物种-Host Species： Mouse
• 修饰-Modification： Unmodified
• 推荐稀释比： WB 1:1000-1:2000;Not yet tested in other applications.
• 组成： Liquid in PBS containing 50% glycerol， 0.5% BSA and 0.02% sodium azide.
• 纯化工艺： Affinity purification
• 储存： -15°C to -25°C/1 year(Do not lower than -25°C)
• 克隆性： Monoclonal
• 免疫原： Purified recombinant human PP2B-Aα protein fragments expressed in E.coli.
• 特异性： PP2B-Aα Monoclonal Antibody detects endogenous levels of PP2B-Aα protein.
• 基因名称： PPP3CA
• 蛋白名称： Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
• Organism-1： Human
• 基因ID-1： 5530
• SwissProt-1： Q08209
• Organism-2： Mouse
• 基因ID-2： 19055
• SwissProt-2： P63328
• Organism-3： Rat
• 基因ID-3： 24674
• SwissProt-3： P63329
• 背景： catalytic activity:A phosphoprotein + H(2)O = a protein + phosphate.，cofactor:Binds 1 Fe(3+) ion per subunit.，cofactor:Binds 1 zinc ion per subunit.，function:Calcium-dependent， calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates HSPB1 and SSH1.，online information:Calcineurin entry，similarity:Belongs to the PPP phosphatase family.，similarity:Belongs to the PPP phosphatase family. PP-2B subfamily.，subcellular location:Colocalizes with ACTN1 and MYOZ2 at the Z line in heart and skeletal muscle.，subunit:Composed of two components (A and B)， the A component is the catalytic subunit and the B component confers calcium sensitivity. Interacts with TORC2/CRTC2， MYOZ1， MYOZ2 and MYOZ3.，
• 细胞定位： Cytoplasm . Cell membrane ; Peripheral membrane protein . Cell membrane， sarcolemma . Cytoplasm， myofibril， sarcomere， Z line . Cell projection， dendritic spine . Colocalizes with ACTN1 and MYOZ2 at the Z line in heart and skeletal muscle (By similarity). Recruited to the cell membrane by scaffold protein AKAP5 following L-type Ca(2+)-channel activation (PubMed:22343722). .

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