• 靶点-Target： HDAC4
• MW(Calculated)： 119kD
• 宿主物种-Host Species： Mouse
• 修饰-Modification： Unmodified
• 推荐稀释比： WB 1:1000-1:2000;Not yet tested in other applications.
• 组成： Liquid in PBS containing 50% glycerol， 0.5% BSA and 0.02% sodium azide.
• 纯化工艺： Affinity purification
• 储存： -15°C to -25°C/1 year(Do not lower than -25°C)
• 克隆性： Monoclonal
• 免疫原： Purified recombinant human HDAC4 (N-terminus) protein fragments expressed in E.coli.
• 特异性： HDAC4 Monoclonal Antibody detects endogenous levels of HDAC4 protein.
• 基因名称： HDAC4
• 蛋白名称： Histone deacetylase 4
• Organism-1： Human
• 基因ID-1： 9759
• SwissProt-1： P56524
• Organism-2： Mouse
• 基因ID-2： 208727
• SwissProt-2： Q6NZM9
• Organism-3： Rat
• 基因ID-3： 363287
• SwissProt-3： Q99P99
• 背景： Histones play a critical role in transcriptional regulation， cell cycle progression， and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly， but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. [provided by RefSeq， Jul 2008]，
• 细胞定位： Nucleus. Cytoplasm. Shuttles between the nucleus and the cytoplasm. Upon muscle cells differentiation， it accumulates in the nuclei of myotubes， suggesting a positive role of nuclear HDAC4 in muscle differentiation. The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its phosphorylation at Ser-246， Ser-467 and Ser-632 by CaMK4 and SIK1. The nuclear localization probably depends on sumoylation. Interaction with SIK3 leads to HDAC4 retention in the cytoplasm (By similarity). .

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