• 靶点-Target： HXK I
• MW(Calculated)： 102kD
• 宿主物种-Host Species： Mouse
• 修饰-Modification： Unmodified
• 推荐稀释比： WB 1:500-1:2000;IHC 1:200-1:1000;IF 1:200-1:1000;Flow Cyt 1:200-1:400;ELISA 1:10000;Not yet tested in other applications.
• 组成： Liquid in PBS containing 50% glycerol， 0.5% BSA and 0.02% sodium azide.
• 纯化工艺： Affinity purification
• 储存： -15°C to -25°C/1 year(Do not lower than -25°C)
• 克隆性： Monoclonal
• 免疫原： Purified recombinant fragment of human HXK I expressed in E. Coli.
• 特异性： HXK I Monoclonal Antibody detects endogenous levels of HXK I protein.
• 基因名称： HK1
• 蛋白名称： Hexokinase-1
• Organism-1： Human
• 基因ID-1： 3098
• SwissProt-1： P19367
• Organism-2： Mouse
• SwissProt-2： P17710
• Organism-3： Rat
• 基因ID-3： 25058
• SwissProt-3： P05708
• 背景： Hexokinases phosphorylate glucose to produce glucose-6-phosphate， the first step in most glucose metabolism pathways. This gene encodes a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria. Mutations in this gene have been associated with hemolytic anemia due to hexokinase deficiency. Alternative splicing of this gene results in several transcript variants which encode different isoforms， some of which are tissue-specific. [provided by RefSeq， Apr 2016]，
• 细胞定位： Mitochondrion outer membrane ; Peripheral membrane protein . Cytoplasm， cytosol . The mitochondrial-binding peptide (MBP) region promotes association with the mitochondrial outer membrane (Probable). Dissociates from the mitochondrial outer membrane following inhibition by N-acetyl-D-glucosamine， leading to relocation to the cytosol (PubMed:27374331). .

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