• 靶点-Target： Cbl
• MW(Calculated)： 100kD
• 宿主物种-Host Species： Mouse
• 修饰-Modification： Unmodified
• 推荐稀释比： WB 1:500-1:2000;IHC 1:200-1:1000;IF 1:200-1:1000;Flow Cyt 1:200-1:400;ELISA 1:10000;Not yet tested in other applications.
• 组成： Liquid in PBS containing 50% glycerol， 0.5% BSA and 0.02% sodium azide.
• 纯化工艺： Affinity purification
• 储存： -15°C to -25°C/1 year(Do not lower than -25°C)
• 克隆性： Monoclonal
• 免疫原： Purified recombinant fragment of human Cbl expressed in E. Coli.
• 特异性： Cbl Monoclonal Antibody detects endogenous levels of Cbl protein.
• 基因名称： CBL
• 蛋白名称： E3 ubiquitin-protein ligase CBL
• Organism-1： Human
• 基因ID-1： 867
• SwissProt-1： P22681
• Organism-2： Mouse
• 基因ID-2： 12402
• SwissProt-2： P22682
• 背景： Cbl proto-oncogene(CBL) Homo sapiens This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia， and expansion of CGG repeats in the 5' UTR has been associated with Jacobsen syndrome. Mutations in this gene are also the cause of Noonan syndrome-like disorder. [provided by RefSeq， Jul 2016]，
• 细胞定位： Cytoplasm. Cell membrane. Cell projection， cilium . Golgi apparatus . Colocalizes with FGFR2 in lipid rafts at the cell membrane.

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