• 靶点-Target： BMPR-II
• MW(Calculated)： 115kD
• 宿主物种-Host Species： Mouse
• 修饰-Modification： Unmodified
• 推荐稀释比： WB 1:500-1:2000;IHC 1:200-1:1000;IF 1:200-1:1000;ELISA 1:10000;Not yet tested in other applications.
• 组成： Liquid in PBS containing 50% glycerol， 0.5% BSA and 0.02% sodium azide.
• 纯化工艺： Affinity purification
• 储存： -15°C to -25°C/1 year(Do not lower than -25°C)
• 克隆性： Monoclonal
• 免疫原： Purified recombinant fragment of human BMPR-II expressed in E. Coli.
• 特异性： BMPR-II Monoclonal Antibody detects endogenous levels of BMPR-II protein.
• 基因名称： BMPR2
• 蛋白名称： Bone morphogenetic protein receptor type-2
• Organism-1： Human
• 基因ID-1： 659
• SwissProt-1： Q13873
• Organism-2： Mouse
• 基因ID-2： 12168
• SwissProt-2： O35607
• 背景： This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs， which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors， but they require their respective type I receptors for signaling， whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension， both familial and fenfluramine-associated， and with pulmonary venoocclusive disea
• 细胞定位： Cell membrane ; Single-pass type I membrane protein.

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