• 靶点-Target： ABCG2
• MW(Calculated)： 72kD
• 宿主物种-Host Species： Mouse
• 修饰-Modification： Unmodified
• 推荐稀释比： WB 1:500-1:2000;IHC 1:200-1:1000;IF 1:200-1:1000;Flow Cyt 1:200-1:400;ELISA 1:10000;Not yet tested in other applications.
• 组成： Liquid in PBS containing 50% glycerol， 0.5% BSA and 0.02% sodium azide.
• 纯化工艺： Affinity purification
• 储存： -15°C to -25°C/1 year(Do not lower than -25°C)
• 克隆性： Monoclonal
• 免疫原： Purified recombinant fragment of human ABCG2 expressed in E. Coli.
• 特异性： ABCG2 Monoclonal Antibody detects endogenous levels of ABCG2 protein.
• 基因名称： ABCG2
• 蛋白名称： ATP-binding cassette sub-family G member 2
• Organism-1： Human
• 基因ID-1： 9429
• SwissProt-1： Q9UNQ0
• Organism-2： Mouse
• 基因ID-2： 26357
• SwissProt-2： Q7TMS5
• 背景： The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1， MDR/TAP， MRP， ALD， OABP， GCN20， White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein， this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta， which may suggest a potential role for this molecule in placenta tissue. Multiple transcript variants encoding different isoforms have been found for this gene.
• 细胞定位： Cell membrane ; Multi-pass membrane protein . Apical cell membrane ; Multi-pass membrane protein . Mitochondrion membrane ; Multi-pass membrane protein . Enriched in membrane lipid rafts. .

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