• 靶点-Target： Nrf2
• MW(Calculated)： 68kD
• MW(Observed)： 75-100kD
• 宿主物种-Host Species： Rabbit
• 同种型-Isotype： IgG
• 修饰-Modification： Acetyl
• 推荐稀释比： WB 1:500-1:2000;IHC: 1:100-300;ELISA 1:10000;IF 1:50-200
• 组成： Liquid in PBS containing 50% glycerol， 0.5% BSA and 0.02% sodium azide.
• 纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• 储存： -15°C to -25°C/1 year(Do not lower than -25°C)
• 浓度： 1 mg/ml
• 克隆性： Polyclonal
• 免疫原： Synthesized acetyl-peptide derived from the C-terminal region of human Nrf2 around the acetylation site of K599.
• 特异性： Acetyl-Nrf2 (K599) Polyclonal Antibody detects endogenous levels of Nrf2 protein only when acetylation at K599.
• 基因名称： NFE2L2
• 蛋白名称： Nuclear factor erythroid 2-related factor 2
• Organism-1： Human
• 基因ID-1： 4780
• SwissProt-1： Q16236
• Organism-2： Mouse
• 基因ID-2： 18024
• SwissProt-2： Q60795
• Organism-3： Rat
• 基因ID-3： 83619
• SwissProt-3： O54968
• 背景： This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been characterized for this gene. [provided by RefSeq， Sep 2015]，
• 细胞定位： Cytoplasm， cytosol . Nucleus . Cytosolic under unstressed conditions: ubiquitinated and degraded by the BCR(KEAP1) E3 ubiquitin ligase complex (PubMed:15601839， PubMed:21196497). Translocates into the nucleus upon induction by electrophilic agents that inactivate the BCR(KEAP1) E3 ubiquitin ligase complex (PubMed:21196497). .

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