• 靶点-Target： Cortactin
• MW(Observed)： 62kD
• 宿主物种-Host Species： Rabbit
• 同种型-Isotype： IgG
• 修饰-Modification： Acetyl
• 推荐稀释比： WB 1:500-1:2000;ELISA 1:10000;Not yet tested in other applications.
• 组成： Liquid in PBS containing 50% glycerol， 0.5% BSA and 0.02% sodium azide.
• 纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• 储存： -15°C to -25°C/1 year(Do not lower than -25°C)
• 浓度： 1 mg/ml
• 克隆性： Polyclonal
• 免疫原： Synthesized acetyl-peptide derived from the Internal region of human Cortactin around the acetylation site of K235.
• 特异性： Acetyl-Cortactin (K235) Polyclonal Antibody detects endogenous levels of Cortactin protein only when acetylation at K235.
• 基因名称： CTTN
• 蛋白名称： Src substrate cortactin
• Organism-1： Human
• 基因ID-1： 2017
• SwissProt-1： Q14247
• Organism-2： Mouse
• 基因ID-2： 13043
• SwissProt-2： Q60598
• 背景： cortactin(CTTN) Homo sapiens This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis， the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene. [provided by RefSeq， May 2010]，
• 细胞定位： Cytoplasm， cytoskeleton . Cell projection， lamellipodium . Cell projection， ruffle. Cell projection， dendrite . Cell projection . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell projection， podosome . Cell junction . Cell junction， focal adhesion . Membrane， clathrin-coated pit . Cell projection， dendritic spine . Cytoplasm， cell cortex . Colocalizes transiently with PTK2/FAK1 at focal adhesions (By similarity). Associated with membrane ruffles and lamellipodia. In the presence of CTTNBP2NL， colocalizes with stress fibers (By similarity). In the presence of CTTNBP2， localizes at the cell cortex (By similarity). In response to neuronal activation by glutamate， redistributes from dendritic spines to the dendritic shaft (By similarity). Colocalizes with DNM2 at the basis of filopodia in hippocampus neuron growth zones (By similarity). .

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