• 靶点-Target： Factor VII LC
• MW(Observed)： 17kD
• 宿主物种-Host Species： Rabbit
• 同种型-Isotype： IgG
• 修饰-Modification： Unmodified
• 推荐稀释比： WB 1:500-1:2000;IHC 1:100-1:300;ELISA 1:20000;IF 1:50-200
• 组成： Liquid in PBS containing 50% glycerol， 0.5% BSA and 0.02% sodium azide.
• 纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• 储存： -15°C to -25°C/1 year(Do not lower than -25°C)
• 浓度： 1 mg/ml
• 克隆性： Polyclonal
• 免疫原： The antiserum was produced against synthesized peptide derived from human FA7. AA range:171-220
• 特异性： Cleaved-Factor VII LC (R212) Polyclonal Antibody detects endogenous levels of fragment of activated Factor VII LC protein resulting from cleavage adjacent to R212.
• 基因名称： F7
• 蛋白名称： Coagulation factor VII
• Organism-1： Human
• 基因ID-1： 2155
• SwissProt-1： P08709
• Organism-2： Mouse
• SwissProt-2： P70375
• 背景： This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form， and is converted to an active form by either factor IXa， factor Xa， factor XIIa， or thrombin by minor proteolysis. Upon activation of the factor VII， a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated， and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions， the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Defects in this gene can cause coagulopathy. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing to generate mature polypeptides. [provided by RefSeq， Aug 2015]，
• 细胞定位： Secreted.

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