• 靶点-Target： F12
• MW(Observed)： 41kD
• 宿主物种-Host Species： Rabbit
• 同种型-Isotype： IgG
• 修饰-Modification： Unmodified
• 推荐稀释比： WB 1:500-1:2000;ELISA 1:20000;Not yet tested in other applications.
• 组成： Liquid in PBS containing 50% glycerol， 0.5% BSA and 0.02% sodium azide.
• 纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• 储存： -15°C to -25°C/1 year(Do not lower than -25°C)
• 浓度： 1 mg/ml
• 克隆性： Polyclonal
• 免疫原： The antiserum was produced against synthesized peptide derived from human FA12. AA range:323-372
• 特异性： Cleaved-Factor XII HC (R372) Polyclonal Antibody detects endogenous levels of fragment of activated Factor XII HC protein resulting from cleavage adjacent to R372.
• 基因名称： F12
• 蛋白名称： Coagulation factor XII
• Organism-1： Human
• 基因ID-1： 2161
• SwissProt-1： P00748
• Organism-2： Mouse
• SwissProt-2： Q80YC5
• 背景： This gene encodes coagulation factor XII which circulates in blood as a zymogen. This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains， two epidermal growth factor (EGF)-like domains， a kringle domain and a proline-rich domain， whereas the light chain contains only a catalytic domain. On activation， further cleavages takes place in the heavy chain， resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein， which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation， fibrinolysis， and the generation of bradykinin and angiotensin. It activat
• 细胞定位： Secreted.

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