• 靶点-Target： COL4A3
• MW(Observed)： 140kD
• 宿主物种-Host Species： Rabbit
• 同种型-Isotype： IgG
• 修饰-Modification： Unmodified
• 推荐稀释比： WB 1:500-1:2000;ELISA 1:5000;Not yet tested in other applications.
• 组成： Liquid in PBS containing 50% glycerol， 0.5% BSA and 0.02% sodium azide.
• 纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• 储存： -15°C to -25°C/1 year(Do not lower than -25°C)
• 浓度： 1 mg/ml
• 克隆性： Polyclonal
• 免疫原： The antiserum was produced against synthesized peptide derived from human Collagen IV alpha3. AA range:1376-1425
• 特异性： Cleaved-COL4A3 (L1425) Polyclonal Antibody detects endogenous levels of fragment of activated COL4A3 protein resulting from cleavage adjacent to L1425.
• 基因名称： COL4A3
• 蛋白名称： Collagen alpha-3(IV) chain
• Organism-1： Human
• 基因ID-1： 1285
• SwissProt-1： Q01955
• Organism-2： Mouse
• SwissProt-2： Q9QZS0
• 背景： Type IV collagen， the major structural component of basement membranes， is a multimeric protein composed of 3 alpha subunits. These subunits are encoded by 6 different genes， alpha 1 through alpha 6， each of which can form a triple helix structure with 2 other subunits to form type IV collagen. This gene encodes alpha 3. In the Goodpasture syndrome， autoantibodies bind to the collagen molecules in the basement membranes of alveoli and glomeruli. The epitopes that elicit these autoantibodies are localized largely to the non-collagenous C-terminal domain of the protein. A specific kinase phosphorylates amino acids in this same C-terminal region and the expression of this kinase is upregulated during pathogenesis. This gene is also linked to an autosomal recessive form of Alport syndrome. The mutations contributing to this syndrome are also located within the exons that encode this C-terminal r
• 细胞定位： Secreted， extracellular space， extracellular matrix， basement membrane. Colocalizes with COL4A4 and COL4A5 in GBM， tubular basement membrane (TBM) and synaptic basal lamina (BL). .

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