• 靶点-Target： Factor XIIIa
• MW(Observed)： 79kD
• 宿主物种-Host Species： Rabbit
• 同种型-Isotype： IgG
• 修饰-Modification： Unmodified
• 推荐稀释比： WB 1:500-1:2000;ELISA 1:20000;Not yet tested in other applications.
• 组成： Liquid in PBS containing 50% glycerol， 0.5% BSA and 0.02% sodium azide.
• 纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• 储存： -15°C to -25°C/1 year(Do not lower than -25°C)
• 浓度： 1 mg/ml
• 克隆性： Polyclonal
• 免疫原： The antiserum was produced against synthesized peptide derived from human FA13A. AA range:20-69
• 特异性： Cleaved-Factor XIIIa (G39) Polyclonal Antibody detects endogenous levels of fragment of activated Factor XIIIa protein resulting from cleavage adjacent to G39.
• 基因名称： F13A1
• 蛋白名称： Coagulation factor XIII A chain
• Organism-1： Human
• 基因ID-1： 2162
• SwissProt-1： P00488
• Organism-2： Mouse
• SwissProt-2： Q8BH61
• 背景： This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function， and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits， which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion， the plasma factor XIII dissociates its B subunits and yields the same active enzyme， factor XIIIa， as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules， thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor， or
• 细胞定位： Cytoplasm. Secreted . Secreted into the blood plasma. Cytoplasmic in most tissues， but also secreted in the blood plasma.

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