• 靶点-Target： COL1A2
• MW(Observed)： 92kD
• 宿主物种-Host Species： Rabbit
• 同种型-Isotype： IgG
• 修饰-Modification： Unmodified
• 推荐稀释比： WB 1:500-1:2000;ELISA 1:10000;Not yet tested in other applications.
• 组成： Liquid in PBS containing 50% glycerol， 0.5% BSA and 0.02% sodium azide.
• 纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• 储存： -15°C to -25°C/1 year(Do not lower than -25°C)
• 浓度： 1 mg/ml
• 克隆性： Polyclonal
• 免疫原： The antiserum was produced against synthesized peptide derived from human Collagen I alpha2. AA range:1053-1102
• 特异性： Cleaved-COL1A2 (G1102) Polyclonal Antibody detects endogenous levels of fragment of activated COL1A2 protein resulting from cleavage adjacent to G1102.
• 基因名称： COL1A2
• 蛋白名称： Collagen alpha-2(I) chain
• Organism-1： Human
• 基因ID-1： 1278
• SwissProt-1： P08123
• Organism-2： Mouse
• SwissProt-2： Q01149
• 背景： This gene encodes the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone， cornea， dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV， Ehlers-Danlos syndrome type VIIB， recessive Ehlers-Danlos syndrome Classical type， idiopathic osteoporosis， and atypical Marfan syndrome. Symptoms associated with mutations in this gene， however， tend to be less severe than mutations in the gene for the alpha1 chain of type I collagen (COL1A1) reflecting the different role of alpha2 chains in matrix integrity. Three transcripts， resulting from the use of alternate polyadenylation signals， have been identified for this gene. [provided by R. Dalgleish， Feb 2008]，
• 细胞定位： Secreted， extracellular space， extracellular matrix .

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