• 靶点-Target： Cathepsin D
• MW(Observed)： 27kD
• 宿主物种-Host Species： Rabbit
• 同种型-Isotype： IgG
• 修饰-Modification： Unmodified
• 推荐稀释比： WB 1:500-1:2000;ELISA 1:40000;Not yet tested in other applications.
• 组成： Liquid in PBS containing 50% glycerol， 0.5% BSA and 0.02% sodium azide.
• 纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• 储存： -15°C to -25°C/1 year(Do not lower than -25°C)
• 浓度： 1 mg/ml
• 克隆性： Polyclonal
• 免疫原： The antiserum was produced against synthesized peptide derived from human CATD. AA range:150-199
• 特异性： Cleaved-Cathepsin D HC (L169) Polyclonal Antibody detects endogenous levels of fragment of activated Cathepsin D HC protein resulting from cleavage adjacent to L169.
• 基因名称： CTSD
• 蛋白名称： Cathepsin D
• Organism-1： Human
• 基因ID-1： 1509
• SwissProt-1： P07339
• Organism-2： Mouse
• SwissProt-2： P18242
• 背景： This gene encodes a member of the A1 family of peptidases. The encoded preproprotein is proteolytically processed to generate multiple protein products. These products include the cathepsin D light and heavy chains， which heterodimerize to form the mature enzyme. This enzyme exhibits pepsin-like activity and plays a role in protein turnover and in the proteolytic activation of hormones and growth factors. Mutations in this gene play a causal role in neuronal ceroid lipofuscinosis-10 and may be involved in the pathogenesis of several other diseases， including breast cancer and possibly Alzheimer's disease. [provided by RefSeq， Nov 2015]，
• 细胞定位： Lysosome. Melanosome. Secreted， extracellular space. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. In aortic samples， detected as an extracellular protein loosely bound to the matrix (PubMed:20551380). .

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