• 靶点-Target： Stat6
• MW(Calculated)： 94kD
• 宿主物种-Host Species： Mouse
• 修饰-Modification： Unmodified
• 推荐稀释比： WB 1:500-1:2000;IF 1:200-1:1000;ELISA 1:10000;Not yet tested in other applications.
• 组成： Liquid in PBS containing 50% glycerol， 0.5% BSA and 0.02% sodium azide.
• 纯化工艺： Affinity purification
• 储存： -15°C to -25°C/1 year(Do not lower than -25°C)
• 克隆性： Monoclonal
• 免疫原： Purified recombinant fragment of human Stat6 expressed in E. Coli.
• 特异性： Stat6 Monoclonal Antibody detects endogenous levels of Stat6 protein.
• 基因名称： STAT6
• 蛋白名称： Signal transducer and activator of transcription 6
• Organism-1： Human
• 基因ID-1： 6778
• SwissProt-1： P42226
• Organism-2： Mouse
• 基因ID-2： 20852
• SwissProt-2： P52633
• 背景： The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors， STAT family members are phosphorylated by the receptor associated kinases， and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L)， which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells， expression of cell surface markers， and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq， May 2010]，
• 细胞定位： Cytoplasm. Nucleus. Translocated into the nucleus in response to phosphorylation.

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