• 靶点-Target： MEK2
• MW(Calculated)： 44kD
• 宿主物种-Host Species： Mouse
• 修饰-Modification： Unmodified
• 推荐稀释比： WB 1:500-1:2000;IF 1:200-1:1000;Flow Cyt 1:200-1:400;ELISA 1:10000;Not yet tested in other applications.
• 组成： Liquid in PBS containing 50% glycerol， 0.5% BSA and 0.02% sodium azide.
• 纯化工艺： Affinity purification
• 储存： -15°C to -25°C/1 year(Do not lower than -25°C)
• 克隆性： Monoclonal
• 免疫原： Purified recombinant fragment of human MEK-2 expressed in E. Coli.
• 特异性： MEK-2 Monoclonal Antibody detects endogenous levels of MEK-2 protein.
• 基因名称： MAP2K2
• 蛋白名称： Dual specificity mitogen-activated protein kinase kinase 2
• Organism-1： Human
• 基因ID-1： 5605
• SwissProt-1： P36507
• Organism-2： Mouse
• 基因ID-2： 26396
• SwissProt-2： Q63932
• Organism-3： Rat
• 基因ID-3： 58960
• SwissProt-3： P36506
• 背景： The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome)， a disease characterized by heart defects， mental retardation， and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene， which is located on chromosome 7， has been identified for this gene. [provided by RefSeq， Jul 2008]，
• 细胞定位： Cytoplasm . Membrane ; Peripheral membrane protein . Membrane localization is probably regulated by its interaction with KSR1. .

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