• 靶点-Target： Lamin A
• MW(Calculated)： 74kD
• 宿主物种-Host Species： Mouse
• 修饰-Modification： Unmodified
• 推荐稀释比： WB 1:500-1:2000;IHC 1:200-1:1000;ELISA 1:10000;IF 1:50-200
• 组成： Liquid in PBS containing 50% glycerol， 0.5% BSA and 0.02% sodium azide.
• 纯化工艺： Affinity purification
• 储存： -15°C to -25°C/1 year(Do not lower than -25°C)
• 克隆性： Monoclonal
• 免疫原： Purified recombinant fragment of human Lamin A expressed in E. Coli.
• 特异性： Lamin A Monoclonal Antibody detects endogenous levels of Lamin A protein.
• 基因名称： LMNA
• 蛋白名称： Lamin-A/C
• Organism-1： Human
• 基因ID-1： 4000
• SwissProt-1： P02545
• Organism-2： Mouse
• 基因ID-2： 16905
• SwissProt-2： P48678
• Organism-3： Rat
• 基因ID-3： 60374
• SwissProt-3： P48679
• 背景： lamin A/C(LMNA) Homo sapiens The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis， the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability， chromatin structure and gene expression. Vertebrate lamins consist of two types， A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy， familial partial lipodystrophy， limb girdle muscular dystrophy， dilated cardiomyopathy， Charcot-Marie-Tooth disease， and Hutchinson-Gilford progeria syndrome. [provided by RefSeq， Apr 2012]，
• 细胞定位： Nucleus . Nucleus envelope . Nucleus lamina. Nucleus， nucleoplasm. Nucleus matrix . Farnesylation of prelamin-A/C facilitates nuclear envelope targeting and subsequent cleavage by ZMPSTE24/FACE1 to remove the farnesyl group produces mature lamin-A/C， which can then be inserted into the nuclear lamina. EMD is required for proper localization of non-farnesylated prelamin-A/C.; [Isoform C]: Nucleus speckle .

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