• 靶点-Target： ESET
• MW(Calculated)： 143kD
• 宿主物种-Host Species： Mouse
• 修饰-Modification： Unmodified
• 推荐稀释比： WB 1:500-1:2000;IF 1:200-1:1000;ELISA 1:10000;Not yet tested in other applications.
• 组成： Liquid in PBS containing 50% glycerol， 0.5% BSA and 0.02% sodium azide.
• 纯化工艺： Affinity purification
• 储存： -15°C to -25°C/1 year(Do not lower than -25°C)
• 克隆性： Monoclonal
• 免疫原： Purified recombinant fragment of human ESET expressed in E. Coli.
• 特异性： ESET Monoclonal Antibody detects endogenous levels of ESET protein.
• 基因名称： SETDB1
• 蛋白名称： Histone-lysine N-methyltransferase SETDB1
• Organism-1： Human
• 基因ID-1： 9869
• SwissProt-1： Q15047
• Organism-2： Mouse
• SwissProt-2： O88974
• 背景： SET domain bifurcated 1(SETDB1) Homo sapiens This gene encodes a histone methyltransferase which regulates histone methylation， gene silencing， and transcriptional repression. This gene has been identified as a target for treatment in Huntington Disease， given that gene silencing and transcription dysfunction likely play a role in the disease pathogenesis. Alternatively spliced transcript variants of this gene have been described.[provided by RefSeq， Jun 2011]，
• 细胞定位： Nucleus . Cytoplasm . Chromosome. Associated with non-pericentromeric regions of chromatin. Excluded from nucleoli and islands of condensed chromatin. .

资料下载