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- accession：NM_005188
- 基因别名：CBL2; NSLL; C-CBL; RNF55; FRA11B
- 基因描述：Homo sapiens Cbl proto-oncogene, E3 ubiquitin protein ligase (CBL), mRNA.
- 载体：现货载体
- CDS区长度：2721
- 翻译后氨基酸长度：906
- 基因简介：This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia. Mutations in this gene are also the cause of Noonan syndrome-like disorder. [provided by RefSeq, Mar 2012]
- 规格：10ul 质粒
CDS区参考序列： 点击查看序列翻译后氨基酸参数序列： 点击查看序列
