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全部 中南大学湘雅二医院 南开大学 中国医科大学附属盛京医院 郑州大学第一附属医院 中南大学湘雅医院 贵州医科大学 中国人民解放军总医院 山东大学 哈尔滨医科大学附属第一医院 复旦大学 西南医科大学 武汉大学人民医院 中南大学湘雅三医院 浙江大学医学院附属第一医院 福建医科大学 江南大学 成都中医药大学 重庆医科大学 延边大学 扬州大学 江苏大学 陆军军医大学新桥医院 武汉大学 安徽医科大学 西北农林科技大学 华南农业大学 第四军医大学 温州医科大学 浙江工业大学 空军军医大学唐都医院 河北医科大学第二医院 川北医学院附属医院 四川大学华西医院 安徽大学 吉林大学 苏州大学附属第一医院 中山大学附属第一医院 温州医科大学附属第一医院 华中农业大学 无 广西医科大学公共卫生学院 西南大学 浙江大学 广东医科大学附属医院 天津医科大学 安徽医科大学第一附属医院 宁波大学附属第一医院 华中科技大学 贵州省人民医院 东南大学 清华大学 西北工业大学 广西医科大学 中国科学院合肥物质科学研究院 浙江中医药大学 南昌大学 南方医科大学 广东海洋大学 中国科学技术大学附属第一医院 湖南农业大学 聊城市人民医院 空军军医大学 西安交通大学第二附属医院 天津中医药大学 遵义医科大学附属医院 大连医科大学 徐州医科大学 北京中医药大学 山东理工大学 长沙理工大学 河北医科大学第三医院 湖北省襄阳市第一人民医院 兰州大学第二医院 安徽中医药大学第一附属医院 蚌埠医学院 天津医科大学肿瘤医院 山西中医药大学 广州医科大学 宁夏医科大学 潍坊医学院 浙江理工大学 湖北师范大学 北京市疾病预防控制中心 山西医科大学第一医院 中国科学院脑科学与智能技术卓越创新中心 College of Life Science, South-Central Minzu University, No. 182, Minyuan Road, Hongshan District, Wuhan City, Hubei Province 430074, China School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China School of Public Health, Guangxi Medical University, Nanning, Guangxi, China Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases, Guangxi Medical University, Nanning, Guangxi, China State Key Laboratory of Systems Medicine for Cancer, Renji-Med X Clinical Stem Cell Research Center, Ren Ji Hospital, School of Medicine and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China School of Biomedical Engineering and Med-X Research Institute, Shanghai Jiao Tong University, Shanghai, China 中南大学湘雅医院肿瘤科 江苏大学附属武进人民医院 哈尔滨医科大学附属第四医院 浙江省人民医院（杭州医学院附属医院）药学部肿瘤中心临床药学中心 College of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, 310053, People’s Republic of China 南方医科大学珠江医院药学部 中国医科大学盛京医院儿科 河北师范大学 澳门科技大学 香港浸会大学 山西省人民医院 深圳市人民医院 温州医科大学附属台州医院 广州医科大学附属妇女儿童医疗中心遗传与内分泌科 广西医科大学附属肿瘤医院 浙江大学医学院附属杭州市第一人民医院 哈尔滨医科大学第一临床医院 浙江大学医学院附属邵逸夫医院 嘉兴大学第二附属医院 义乌市中心医院（温州医科大学附属义乌医院）心内科 江汉大学医学院 School of Power and Mechanical Engineering, The Institute of Technological Science, Wuhan University, Wuhan, 430072, China 皖南医学院第一附属医院 青岛大学 徐州医科大学附属口腔医院 安徽医科大学附属合肥医院（合肥市第二人民医院） Caifeng Yue and Jierong Chen contributed equally to this work. Department of Laboratory Medicine, Central People’s Hospital of Zhanjiang, Guangdong Medical University Zhanjiang Central Hospital, 236 Yuanzhu Road, 524045, Zhanjiang, P. R. China 北京中医医院顺义医院 中国医学科学院北京协和医学院肿瘤医院 南方科技大学第一附属医院（深圳市人民医院） 广州中医药大学第四临床医学院 中山大学附属第三医院 深圳市中医医院 无锡市红十字中心血站检验科 军事医学研究院辐射医学研究所 武汉科技大学附属普仁医院 锦州医科大学附属第一医院 阜阳师范大学 上海市长征医院 广州医科大学附属第一医院 武汉大学人民医院（又名湖北省人民医院） 苏州大学常州肿瘤医院 兰州大学第二医院暨临床医学院 南昌大学江西医学院第二附属医院 中国农业科学院兰州畜牧与兽药研究所动物科学系 浙江省人民医院（杭州医学院附属医院） 福建医科大学附属第一医院 云南大学 柳州市柳铁中心医院 江苏省人民医院 北京化工大学 北京工商大学 中国科学院过程工程研究所 中国科学院生物物理研究所 南昌大学江西医学院 福州大学 同济大学医学院附属上海市第十人民医院 广东省人民医院（广东省医学科学院）、南方医科大学 陆军军医大学（第三军医大学）第一附属医院（西南医院） 首都医科大学 郑州大学人民医院（河南省人民医院 These authors contributed equally: Hao Peng, Meng Yang Medical School, Southeast University, Nanjing, 210009, China 新乡市中心医院 郑州大学附属肿瘤医院/河南省肿瘤医院 中国中医科学院 上海海洋大学 天津医科大学眼科医院 温州医科大学基础医学院 中国人民解放军医学院 中国医科大学第四附属医院 长治医学院附属和平医院 西安交通大学第一附属医院 中山大学 海口市人民医院/中南大学湘雅医学院附属海口医院 国家生物医学分析中心 上海纳米生物材料与再生医学工程研究中心 中国医学科学院北京协和医学院 潍坊医学院附属医院 首都医科大学附属北京潞河医院 赣南医科大学第一附属医院 安徽理工大学 河北省人民医院 首都医科大学附属北京天坛医院 杭州医学院附属医院浙江省人民医院 宝鸡市人民医院 安徽省第二人民医院 中山大学附属第八医院 南京农业大学 贵州省贵阳市第二人民医院 蚌埠医学院第一附属医院 湖北省中医院 山西医科大学第三医院 郑州大学第五附属医院 海南医学院第一附属医院（海南医学院海南医院） 哈尔滨医科大学 浙江省人民医院（杭州医学院附属医院 中国医科大学盛京医院 中山大学孙逸仙纪念医院 昆明医科大学第一附属医院 广西壮族自治区人民医院 河北北方学院第一附属医院 沈阳农业大学 贵州大学 承德医学院 厦门理工学院 浙江中医药大学第一附属医院（浙江省中医院 河北医科大学第四医院 中国广州华南农业大学 徐州医科大学宿迁医院（南京鼓楼医院集团宿迁医院） 中南大学湘雅 遵义医科大学 中国科学院长春兽医研究所 河北眼科医院 江苏省肿瘤医院 云南省肿瘤医院（昆明医科大学第三附属医院） 陕西中医药大学 徐州医科大学附属连云港东方医院 福建医科大学附属第二医院 复旦大学附属中山医院 上海交通大学医学院附属胸科医院 石河子大学 宝鸡市人民医院普外科 华北理工大学 苏州大学苏州医学院附属第一医院 武汉生物制品研究所有限责任公司 辽宁师范大学 牡丹江医科大学 长江大学

¹Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China

²Department of Clinical Laboratory, Wenzhou People’s Hospital, Wenzhou, China

³Department of Hepatobiliary Surgery, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China

⁴Key Laboratory of Intelligent Treatment and Life Support for Critical Diseases of Zhejiang Province, Wenzhou, Zhejiang, China

⁵Zhejiang Engineering Research Center for Hospital Emergency and Process Digitization, Wenzhou, Zhejiang, China

中国医科大学附属第四医院 海南省肿瘤医院 海军军医大学长征医院 中国医学科学院北京协和医学院阜外医院 广东医科大学附属东莞第一医院 暨南大学 厦门大学 长春中医药大学 南通大学第六附属医院（盐城市第三人民医院） 山东中医药大学 成都市第二人民医院 中国科学院成都生物研究所 四川大学 中国科学院广州动物研究所 重庆大学 南华大学 佳木斯大学 河北省沧州市中心医院 湖南师范大学 山东省青岛市市立医院口腔医学中心 贵州医科大学附属医院 武汉大学中南医院 烟台山医院 浙江省同德医院 南昌大学第一附属医院 中国科学院北京基因组研究所 宁夏大学 河北大学 宁波大学 福建医科大学附属协和医院 甘肃省泌尿外科临床医学研究中心 宁夏医科大学基础医学院 温州医科大学第一附属医院 贵州省茅台医院 成都医学院第一附属医院 第二军医大学 南京中医药大学中西医结合临床医学院 南方医科大学附属东莞医院 天津医科大学口腔医学院 苏州大学医学院 清华大学深圳国际研究生院Open FIESTA中心 苏州大学附属儿童医院 西安医学院第三附属医院 北京大学肿瘤医院（内蒙古院区） 中国人民共和国安庆医学院 安徽省医学科学院 江苏大学附属武进医院 南华大学衡阳医学院 第一附属医院 衡阳市中心医院 山东省第一医科大学附属医院 福建医科大学附属泉州第一医院 山西省肿瘤医院 重庆医科大学医学 北京农学院 南昌大学第二附属医院 南方医科大学第十附属医院 茂名市人民医院 昆明理工大学 中国科学院长春应用化学研究所 中国科学院昆明植物研究所 温州医科大学附属第二医院 同济大学 内蒙古科技大学 江西医学院 中国农业科学院 中国药科大学 福建医科大学附属福州第一医院 河北医科大学 中国科学技术大学第一附属医院 江苏医药职业学院 中国重庆医科大学 中南大学基础医学院 大理大学 暨南大学广州红十字会医院 南通大学第二附属医院 青岛大学附属医院 湖北医药学院附属襄阳第一人民医院 中国医学科学院北京协和医学院国家癌症中心 河北医科大学第一医院心内科 赤峰学院附属医院 深圳大学医学部第一附属医院 沧州市中心医院 苏州大学 台州医院（温州医科大学附属医院） 广西医科大学第一附属医院 中国人民解放军总医院第一医学中心 云南贝泰妮生物科技集团股份有限公司 黄冈市中心医院 深圳市龙岗区人民医院 & 香港中文大学（深圳）医学院附属第二医院 南方医科大学南方医院 石河子大学药学院 康诺亚生物医药科技（成都）有限公司 北京工业大学 首都医科大学附属北京世纪坛医院 河北省承德市中心医院 Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, P.R. China 襄阳市第一人民医院 浙江省人民医院 山东大学齐鲁医学院 中山大学深圳校区 武汉市红十字会医院 湖南省肿瘤医院 广州中医药大学 首都医科大学附属北京安贞医院 江西医科大学第一附属医院 中国人民武装警察部队特色医学中心 黑龙江八一农垦大学 国家癌症中心" 北京理工大学 南京医科大学第二附属医院 深圳大学 山东第一医科大学第一附属医院（山东省千佛山医院 天津医科大学第二医院 济宁医学院附属医院 中国人民解放军消化疾病研究所 长江大学荆州市附属医院 山东滨州医学院 烟台大学 内蒙古医科大学附属医院 西安交通大学 哈尔滨师范大学 中国海洋大学 开封市开封儿童医院 桂林医学院 南京中医药大学附属医院（江苏省中医院） 湖南医药学院第一附属医院 南京林业大学 山东第一医科大学 广东药科大学 华南理工大学 湖北省帕金森病研究所（襄阳第一人民医院） 新加坡国立大学 南京大学 济南大学 中国重庆医科大学附属第一医院 中国医科大学 Faculty of Materials Science and Chemical Engineering, Ningbo University, Ningbo 315211, China b Zhejiang International Scientific and Technological Cooperative Base of Biomedical Materials and Technology, Cixi Institute of Biomedical Engineering, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315300, China Department of Orthopaedic Surgery, The Third Hospital of Hebei Medical University, 139#Ziqiang Road, Shijiazhuang, Hebei Province, China Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Department of Chemistry, Fudan University, Shanghai 200438, China Department of Clinical Laboratory, The Second Hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei Province, People’s Republic of China Basic Medical School of Ningxia Medical University, Yinchuan, 750004, China Institute of Endocrinology, Ningxia Medical University, Yinchuan, 750004, China Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education, Ningxia Medical University, Yinchuan, 750004, China 1 Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, People’s Republic of China, pppwwwsss@163.com; yangxg123@163.com Medical Research Institute, College of Pharmaceutical Sciences, Southwest University, Chongqing, 400715 P. R. China Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Institute of Infection, Immunology and Tumor Microenvironment, School of Medicine, Wuhan University of Science and Technology, Wuhan, Hubei, China Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China Orthopedic Laboratory of Chongqing Medical University, Chongqing, 400016, China College of Food Science and Engineering, Ocean University of China, No.5, Yushan Road, Qingdao, Shandong Province, 266003, PR China The Fifth Affiliated Hospital of Xinjiang Medical University, department of gynaecology and obstetrics, Urumqi, Xinjiang 830011, PR China Department of Neonatology, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou, Hubei Province, China Xijing hospital 1. Department of Clinical Laboratory, the Second Affiliated Hospital and Yuying Children's hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, China. 2. State Key Laboratory of Ophthalmology, Optometry and Vision Science, Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325000, China. 3. Pediatric Fundus Department, School of Optometry and Ophthalmology, Eye Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China. 4. The Key Laboratory of Pediatric Hematology and oncology Diseases of Wenzhou, The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, China. Research Center for Environment and Female Reproductive Health, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China Department of Toxicology, School of Public Health, Fujian Medical University, Fuzhou, China State Key Laboratory of Mariculture Breeding, Key Laboratory of Healthy Mariculture for the East China Sea, Engineering Research Center of the Modern Technology for Eel Industry, Ministry of Education, Fisheries College, Jimei University, Xiamen, Fujian Province, 361021, China Division of Thyroid Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, 610041, China Laboratory of Thyroid and Parathyroid Disease, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, 610041, China Beijing Key Laboratory of Lignocellulosic Chemistry, Beijing Forestry University, Beijing 100083, PR China Tingting JiangZailin YangQiuyu SuLiang FangQing XiangCheng TianQinlin GaoChengde MaoCheng Zhi Huang*Hua Zuo College of Food Science and Engineering, Collaborative Innovation Center for Modern Grain Circulation and Safety, Key Laboratory of Grains and Oils Quality Control and Processing, Nanjing University of Finance and Economics, Nanjing 210023, China Changsheng ChenDeguang WuZhen WangLanlan LiuJinmei HeJian LiBin Chu*Song Wang*Bo Yu*Weiqiang Liu Institute of Biotechnology, Key Laboratory of Chemical Biology and Molecular Engineering of National Ministry of Education, Shanxi University, Taiyuan 030006, China College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Road, Hangzhou, Zhejiang 310058, P. R. China Department of Biomedical Engineering, College of Chemistry and Materials Science, Jinan University, Guangzhou 510632, P. R. China Key Laboratory of Biomedical Materials and Implant Devices, Research Institute of Tsinghua University in Shenzhen, Shenzhen 518057, P. R. China Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China State Key Laboratory of Metastable Materials Science and Technology, Nano-Biotechnology Key Lab of Hebei Province, Applying Chemistry Key Lab of Hebei Province, Yanshan University, Qinhuangdao 066004, P. R. China School of Pharmacy, Second Military Medical University, Shanghai 200433, China School of Pharmacy, Shenyang Key Laboratory of Intelligent Mucosal Drug Delivery Systems, Shenyang Pharmaceutical University, Shenyang 110016, China School of Clinical Medicine, Bengbu Medical College, Bengbu, 233030, China School of Life Sciences, Shanghai University, Shanghai, China School of Medicine, Shanghai University, Shanghai, China Department of Geriatric Medicine, Maanshan People’s Hospital, China 2 Department of Clinical Laboratory, The Second Affiliated Hospital of Wannan Medical College, Wuhu, China Department of General Surgery, The First Affiliated Hospital of USTC, Division of Life Science and Medicine, University of Science and Technology of China, Hefei, 230027 China Key Laboratory of Immune Response and Immunotherapy, School of Basic Medical Sciences, Division of Life Science and Medicine, University of Science and Technology of China, Hefei, 230027 China MOE International Joint Research Laboratory on Synthetic Biology and Medicines, School of Biology and Biological Engineering, South China University of Technology, Guangzhou, 510006, PR China The State Key Laboratory of Chemical Oncogenomics, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China Institute of Biomedical Health Technology and Engineering, Shenzhen Bay Laboratory, Shenzhen, 518132, China These authors contributed equally to this Department of Toxicology, School of Public Health, Fujian Medical University, Fuzhou 350122, China Research Center for Environment and Female Reproductive Health, the Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen 518033, China Key Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, China Department of Laboratory Medicine, The Second Affiliated Hospital of Dalian Medical University, Dalian, 2 Department of Urology, Laizhou People's Hospital, Laizhou, China Department of Gynaecology, Xingtai People’s Hospital, Xingtai, Hebei 054000, People’s Republic of China; 2Department of Obstetrics and Gynecology, Xingtai People’s Hospital, Xingtai, Hebei 054000, People’s Republic of China Correspondence: Yue Ren Department of Gynaecology, Xingtai People’s Hospital, Xingtai, Hebei 054000, People’s Republic of China Guangdong Provincial Key Laboratory of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou, 510642, Guangdong, China Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou, 510642, China College of Pharmacy, Institute of Ethnomedicine, Southwest Minzu University, Chengdu 610041, China School of Public Health, Guangxi Medical University, 22 Shuangyong Road, Nanning, 530021, Guangxi, China Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases, Guangxi Medical University, Nanning, 530021, Guangxi, China Department of Pediatrics Hematology-Oncology, the Second Hospital of Hebei Medical University, Shijiazhuang 050000, China Corresponding author: Mao Ye, PhD, Department of General Surgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, No. 88, Jiefang Road, Shangcheng District, Hangzhou 310009, Zhejiang Province, P.R. China. College of Health Science and Engineering, Hubei University, Wuhan 430062, China Department of Gynecology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China 2Department of Gynecology, Cangzhou People’s Hospital, Cangzhou, Hebei, China 3Department of Gynecology, Hebei General Hospital, Shijiazhuang, Hebei, China 4Department of Gynecology, The First Hospital of Qinhuangdao, Qinhuangdao, Hebei, China Tian Xu and Li Zhang have contributed equally to this work. School of Environmental Science and Engineering, Wuxi University, Wuxi, 214105, China Hunan Agricultural University, 2 Wuhan Animal Disease Control Center College of Veterinary Medicine, Hebei Agricultural University, Baoding, PR China These authors contributed equally to this work. Corresponding author at: College of Veterinary Medicine, Hebei Agricultural University, No. 2596 Lekai South Street, Lianchi District, Baoding 071000, PR China. Departments of Oncology, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China Department of Ophthalmology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China Center for Medical Research, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China Department of Biliary-Pancreatic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, P.R. China Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, P.R. China Department of Clinical Pharmacology, School of Pharmacy, China Medical University, Shenyang, Liaoning, China School of Basic Medical Sciences, Binzhou Medical University, Yantai, China College of Pharmacy, Guangxi University of Chinese Medicine, Nanning, China Beijing Key Laboratory Research on Liver Regeneration and Artificial Liver Transformation, Fourth Department of Liver Disease, Beijing Youan Hospital, Capital Medical University, Beijing, China Beijing Institute of Hepatology, Beijing Youan Hospital, Capital Medical University, Beijing, China Otorhinolaryngology – Head and Neck Surgery, Gansu Provincial Hospital, Lanzhou, China State Key Laboratory of Metastable Materials Science and Technology, Nano-biotechnology Key Lab of Hebei Province, Applying Chemistry Key Lab of Hebei Province, Yanshan University, Qinhuangdao, Hebei, 066004 China Department of Orthopedics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, 200030 China School of Environmental and Chemical Engineering, Jiangsu University of Science and Technology, Zhenjiang, 212003 P.R. China Shanghai Key Laboratory of Molecular Imaging, Jiading District Central Hospital Affiliated Shanghai University of Medicine and Health Sciences, Shanghai, China 中南大学湘雅口腔医院/湘雅口腔医学院，湖南省数智化与个体化诊疗技术工程研究中心，湖南省3D打印 口腔医疗工程技术研究中心，口腔颌面再生王松灵院士专家工作站，长沙 410078 Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, Key Laboratory of Science & Technology of Eco-Textile (Ministry of Education), College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, 201620, PR China The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China These authors contributed equally to this work. TCM and Ethnomedicine Innovation and Development International Laboratory, Innovative Materia Medica Research Institute, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, China 2Department of Chemistry, Karakoram International University, Gilgit, Pakistan 3Hunan Province Key Laboratory of Plant Functional Genomics and Developmental Regulation, College of Biology, Hunan University, Changsha, China 4Clinic Experimental Research Center, The First People’s Hospital of Huaihua, Huaihua, China Department of Nuclear Medicine, The First Hospital of Hunan University of Chinese Medicine, Changsha, China Institute of Public Health, Chengdu University of Traditional Chinese Medicine, Chengdu, China State Key Laboratory of Metastable Materials Science and Technology, Nano-biotechnology Key Lab of Hebei Province, Applying Chemistry Key Lab of Hebei Province, Yanshan University, Qinhuangdao066004, P. R. China The State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, 550025, Guiyang, China The Department of Pharmacology of Materia Medica (The High Efficacy Application of Natural Medicinal Resources Engineering Center of Guizhou Province and the High Educational Key Laboratory of Guizhou Province for Natural Medicinal Pharmacology and Druggability), School of Pharmaceutical Sciences, Guizhou Medical University, 550025, Guiyang, China The Key Laboratory of Optimal Utilization of Natural Medicine Resources (The Union Key Laboratory of Guiyang City-Guizhou Medical University), School of Pharmaceutical Sciences, Guizhou Medical University, 550025, Guiyang, China Department of Dermatology, Xiangya Hospital Central South University, Changsha, China National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Changsha, China Furong Laboratory, Changsha, China a College of Food Science & Technology, Shanghai Ocean University, Shanghai 201306, PR China b Shanghai Engineering Research Center of Aquatic-Product Processing & Preservation, Shanghai 201306, China c Laboratory of Quality and Safety Risk Assessment for Aquatic Products on Storage and Preservation (Shanghai), Ministry of Agriculture, Shanghai 201306, China d National R&D Branch Center for Freshwater Aquatic Products Processing Technology (Shanghai), Shanghai 201306, China e Shanghai Qinpu Biotechnology Pte Ltd, Shanghai 201306, China f School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China g College of Food and Pharmacy, Zhejiang Ocean University, Zhoushan 316000, Zhejiang, China h Shanghai Sixth People's Hospital, Shanghai 201306, China Department of Vascular Surgery, The First Hospital of Jilin University, Changchun 130021, PR China Department of Oncology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, People’s Republic of China Department of Stomatology, Linyi People’s Hospital, Linyi 276000, Shandong, P.R. China National Key Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China Faculty of Synthetic Biology, Shenzhen Institute of Advanced Technology, Shenzhen, 518055, China University of Chinese Academy of Sciences, Beijing, 100101, China Jiangxi Provincial Key Laboratory for Animal Health, Institute of Animal Population Health, College of Animal Science and Technology, Jiangxi Agricultural University, No. 1101 Zhimin Avenue, Economic and Technological Development District, Nanchang 330045, Jiangxi, PR China Department of Anesthesiology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, PR China Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China MOE Key Laboratory of Protein Sciences, School of Pharmaceutical Sciences, MOE Key Laboratory of Bioorganic Phosphorus Chemistry Chemical Biology, Tsinghua University, Beijing 100084, China Chunyan LiaoXiang WangXueying ZhouDequan WangZiyin ZhangYan LiuXiao WuYing ChenYifeng Tan Department of Laboratory Medicine, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, Shandong, China Postdoctoral Mobile Station of Shandong University, Jinan, Shandong, China College of Animal Science and Technology, Shihezi University, Shihezi, China Collaborative Innovation Center for Sheep Health Breeding and Zoonotic Disease Prevention and Control, Shihezi, Xinjiang, China International Joint Research Center for Animal Health, Shihezi, Xinjiang, China Department of Polymer Materials, Zhejiang Sci-Tech University, Hangzhou 310018, China Zhejiang Sci-Tech University Shengzhou Innovation Research Institute, Shengzhou 312451, China College of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang 550025, China State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China Natural Products Research Center of Guizhou Province, Guiyang 550014, China Department of Anatomy, Basic Medical College of Xinjiang Medical University, Urumqi, Xinjiang, P.R. China. 2 Department of Spinal Surgery, The Fourth Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, P.R. China. 3 Department of Traumatology, The Second Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang, Shanxi P.R. China. 4 Department of Nutrition and Food Hygiene, School of Public Health Xinjiang Medical University, Urumqi, Xinjiang, P.R. China. 5 Central South University School of Basic Medical Sciences, Changsha, Hunan P.R. China. The Marine Biomedical Research Institute, Guangdong Medical University, Zhanjiang, Guangdong 524023, China The Marine Biomedical Research Institute of Guangdong Zhanjiang, Zhanjiang, Guangdong 524023, China Correspondence to: L. Luo, The Marine Biomedical Research Institute, Guangdong Medical University, Zhanjiang, Guangdong 524023, China. Nephrology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China 1Institute of Traditional Chinese Medicine, Chengde Medical College, Chengde, China. 2Hebei Province Key Research Office of Traditional Chinese Medicine against Dementia, Hebei Province Key Laboratory of Traditional Chinese Medicine Research and Development, Hebei Key Laboratory of Nerve Injury and Repair, Chengde, China. Research Unit of Nanocatalytic Medicine in Specific Therapy for Serious Disease, State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Medical Sciences (2021RU012), Shanghai 200050, People’s Republic of China Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing 100049, People’s Republic of China School of Life Science and Technology, Inner Mongolia University of Science and Technology, Baotou 014010, China Tianjin State Key Laboratory of Modern Chinese Medicine, School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China Institute of Nano Biomedicine and Engineering, Department of Instrument Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China Department of Pharmacy, School of Food and Pharmacy, Zhejiang Ocean University, Zhoushan, China Engineering Research Center of Cell & Therapeutic Antibody, Ministry of Education, School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, PR China Yi-Kao HuYi-Ming LiuXiao-Lin BaiChao Ma*Xun Liao State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, PR China Department of Foot and Ankle Surgery, Honghui Hospital, Xi'an Jiaotong University, Xi'an, China Contribution: Formal analysis, Writing - original draft, Writing - review & editing Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Harbin 150040, PR China Engineering Research Center of Forest Bio-Preparation, Ministry of Education, Northeast Forestry University, Harbin 150040, PR China College of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, Harbin 150040, PR China Department of Strabismus and Pediatric Ophthalmology, The Second Hospital of Jilin University, Changchun, People’s Republic of China Department of Internal Medicine-Oncology, The Affiliated Dongguan Songshan Lake Central Hospital, Guangdong Medical University, Dongguan, 523326, China 1 Shanghai Ocean University, 2 Tianjin University of Traditional Chinese Medicine, 3 Zhejiang Ocean University, 4 Shanghai Sixth People's Hospital State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, 2 Guangdong Provincial Engineering Research Center of Molecular Imaging, the Fifth Affiliated Hospital, Sun Yat-sen University Institute of Military Cognition and Brain Sciences, Beijing 100850, China Institute of Radiation Medicine, Beijing 100850, China College of Materials and Metallurgy, Guizhou University, Guiyang, 550025, China Department of Cardiovascular Surgery, Tianjin Medical University General Hospital, Tianjin, China Department of Hematology, The Affiliated Hospital of Jinggangshan University, Ji’an, 343000, Jiangxi Province, People’s Republic of China School of Biomedical Sciences, University of Western Australia, Crawley, WA, 6009, Australia Department of Chemistry, The University of Hong Kong, Hong Kong SAR, 999077, China School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China Department of Pharmacy, Children’s Hospital of Soochow University, Suzhou 215003, China Lingling Wang,Guoliu Ye,Yan Wang &Caizhi Wang 1 Department of General Surgery, Panyu District Central Hospital, Guangzhou, China 2 Department of Electron Microscopy, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China Department of Pediatrics, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China, Department of Pediatrics, Binzhou Medical University Hospital, Binzhou, Shandong, China Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China Department of Thoracic Surgery, Zhongnan Hospital of Wuhan University, Wuhan 430071, China Hubei Key Laboratory of Tumor Biological Behaviors & Hubei Provincial Clinical Research Center for Cancer, Wuhan 430071, China School of Life Sciences and Health Engineering, Jiangnan University, Wuxi, China Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310032, China College of Ecological Environment Engineering, Qinghai University, Xining 810016, China 2 College of Tibetan Medicine, Qinghai University, Xining 810016, China 3 Medical Department, Qinghai University, Xining 810016, China 4 State Key Laboratory of Plateau Ecology and Agriculture, Qinghai University, Xining 810016, China * Authors to whom correspondence should be addressed. † These authors contributed equally to this work. Wujin Institute of Molecular Diagnostics and Precision Cancer Medicine of Jiangsu University, Wujin Hospital Affiliated with Jiangsu University, Changzhou, 213017, Jiangsu, China Laboratory Department, Zhenjiang Center for Diseases Control and Prevention, Zhenjiang, 212000, China Department of Laboratory Medicine, Affiliated Hospital of Zunyi Medical University, 149 Dalian Road, Zunyi, 563000, Guizhou, China School of Laboratory Medicine, Zunyi Medical University, Zunyi, 563000, Guizhou, China School of Food Science and Technology, Jiangnan University, Wuxi, 214122, China Department of Rehabilitation Medicine, The First Hospital of China Medical University, Shenyang, China Hebei Key Laboratory of Preventive Veterinary Medicine, College of Animal Science and Technology, Hebei Normal University of Science and Technology, Qinhuangdao, China School of Life Sciences, Faculty of Medicine, Tianjin Engineering Center of Micro-Nano Biomaterials and Detection-Treatment Technology, Tianjin Key Laboratory of Function and Application of Biological Macromolecular Structures, Tianjin University, Tianjin 300072, China College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China PLA General Hospital (PLA Medical School), Beijing, China Department of Clinical Laboratory Medicine, The First Medical Center of PLA General Hospital, Beijing, China Contribution: Data curation (lead), Methodology (lead), Validation (lead), Visualization (lead), Writing - original draft (lead), Writing - review & editing (equal) Department of Biomedical Engineering, College of Future Technology, National Biomedical Imaging Center, Peking University, Beijing 100871, China State Key Laboratory of Organic-Inorganic Composites, Beijing Laboratory of Biomaterials, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China Medical College of Soochow University, No. 1, Shizi Street, Suzhou, Jiangsu Province, 215021, P.R. China Department of Neurology, The First Affiliated Hospital of Jinzhou Medical University, No. 2, Section 5, Renmin Street, Jinzhou, Liaoning Province, 121000, P.R. China School of Stomatology, Lanzhou University, Lanzhou, Gansu 730000, China Clinical Research Center for Oral Diseases, Lanzhou, Gansu 730000, China 1 Department of General Surgery, The Second Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China 2 Internal Medicine-Cardiovascular Department, Jiangsu University Affiliated Hospital, Zhenjiang, Jiangsu, China 3 Cancer Institute, Xuzhou Medical University, Xuzhou, Jiangsu, China 4 Jiangsu Provincial People’s Hospital, Nanjing, Jiangsu, China aWest China School of Pharmacy, Sichuan University, Chengdu 610041, China bDepartment of Biomedicine, Collaborative Innovation Center of Sichuan for Elderly Care and Health, Chengdu Medical College, Chengdu 610500, China. E-mail: YZYCDYX@cmc.edu.cn cDepartment of Cell Biology, Institute of Biological Medicine, Jinan University, Guangzhou 510632, China Department of Breast Surgery, Wu Jin Hospital of Jiangsu University, Changzhou 213000, China a Department of Preventive Medicine, School of Public Health, Fujian Medical University, Fuzhou, China;b Fujian Provincial Key Laboratory of Environmental Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou, China;c The Key Laboratory of Environment and Health, School of Public Health, Fujian Medical University, Fuzhou, China Department of Pathology, Yijishan Hospital, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui 241001, China National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074 China Department of Endocrinology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, P.R. China, Department of Cardiology, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230601, P.R. China, Department of Endocrinology, Anhui No. 2 Provincial People's Hospital, Hefei, Anhui 230041, P.R. China, Department of International Medical Service, The First Affiliated Hospital of University of Science and Technology of China, Hefei, Anhui 230001, P.R. China The Research Center of Chiral Drugs, Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China Shanghai Frontiers Science Center for Traditional Chinese Medicine Chemical Biology, Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China State Key Laboratory of Marine Food Processing and Safety Control, National Engineering Research Center of Seafood, Dalian Polytechnic University, Dalian, 116034, China School of Food Science and Technology, Dalian Polytechnic University, Dalian, 116034, China Cancer Center, Department of Gastroenterology, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, 310014 China Department of Geriatrics, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, People's Republic of China These authors contributed equally: Qingqing Zhao, Wei He. Department of General Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China 1 College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China 2 Zhejiang Key Laboratory of Multiomics and Molecular Enzymology, Yangtze Delta Region Institute of Tsinghua University, Zhejiang, Jiaxing 314006, China 3 AGECODE R&D Center, Yangtze Delta Region Institute of Tsinghua University, Zhejiang, Jiaxing 314000, China 4 Beijing Yiqing Daily Chemical Co., Ltd., Tongzhou 101100, China 5 Harvest Biotech (Zhejiang) Co., Ltd., Jiaxing 314000, China * Authors to whom correspondence should be addressed. † These authors contributed equally to this work. 1Academy of Medical Sciences, Zhengzhou University, Zhengzhou 450003, Henan Province, China 2Department of Hepato-Biliary-Pancreatic Surgery, Zhengzhou University People’s Hospital & Henan Provincial People’s Hospital, Zhengzhou 450003, Henan Province, China The Third Xiangya Hospital of Central South University, Changsha, China 1 Qihan Bio Inc., Hangzhou, Zhejiang, China 2 Bone Marrow Transplantation Center of The First Affiliated Hospital & Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China 3 Institute of Immunology and Department of Rheumatology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China 4 Women’s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China 5 Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang, China 6 Johns Hopkins University Hospital, Department of Neurology, Baltimore, MD, USA 7 Department of Genetics, Harvard Medical School, Boston, MA, USA 8 These authors contributed equally a Department of Ultrasound, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, P.R. China 1 School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China 2 The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou 450046, China 3 Co-Construction Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan & Education Ministry of China, Zhengzhou 450046, China * Author to whom correspondence should be addressed. Department of Gastroenterology, the First Affiliated Hospital (Southwest Hospital), Third Military Medical University (Army Medical University), Chongqing, China Insitute of Digestive Diseases of PLA, the First Affiliated Hospital (Southwest Hospital), Third Military Medical University (Army Medical University), Chongqing, China Center for Cholestatic Liver Diseases and Center for Metabolic Associated Fatty Liver Disease, the First Affiliated Hospital (Southwest Hospital), Third Military Medical University (Army Medical University), Chongqing, China 1Department of Radiation Oncology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China 2National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China 3Tianjin’s Clinical Research Center for Cancer, Tianjin, China 4Key Laboratory of Cancer Prevention and Therapy, Tianjin, China 5The Third Department of Medical Oncology, General Hospital of Ningxia Medical University, Yinchuan, China 6The First Department of Medical Oncology, General Hospital of Ningxia Medical University, Yinchuan, China 7Department of Pathology, General Hospital of Ningxia Medical University, Yinchuan, China State Key Laboratory of Systems Medicine for Cancer, Renji-Med X Clinical Stem Cell Research Center, Ren Ji Hospital, School of Medicine and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China 2School of Biomedical Engineering and Med-X Research Institute, Shanghai Jiao Tong University, Shanghai, China Department of Pediatrics, Maternity and Child Health Care Hospital Affiliated to Anhui Medical University (Anhui Maternity and Child Health Care Hospital), Hefei, Anhui, China Jiangsu University, Zhenjiang 212013, China The State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, No.6 Ankang Avenue, Guiyang city and Guian New District, Guizhou 561113, China The Department of Pharmacology of Materia Medica (The High Efficacy Application of Natural Medicinal Resources Engineering Center of Guizhou Province and The High Educational Key Laboratory of Guizhou Province for Natural Medicinal Pharmacology and Druggability), School of Pharmaceutical Sciences, Guizhou Medical University, No.6 Ankang Avenue, Guiyang city and Guian New District, Guizhou 561113, China The Key Laboratory of Optimal Utilization of Natural Medicine Resources (The Union Key Laboratory of Guiyang City-Guizhou Medical University), School of Pharmaceutical Sciences, Guizhou Medical University, No.6 Ankang Avenue, Guiyang city and Guian New District, Guizhou 561113, China Key Laboratory of the Three Gorges Reservoir Region’s Eco-Environment, State Ministry of Education, Chongqing University, Chongqing 400045, PR China State Key Laboratory of Coal Mine Disaster Dynamics and Control, Chongqing University, Chongqing 400044, PR China a School of Chemistry and Chemical Engineering, University of Jinan, Jinan, 250022, China b School of Biological Science and Technology, University of Jinan, Jinan, 250022, China Anhui University of Science and Technology, 232001 Huainan, Anhui, China.2Department of Neurosurgery, The First Affiliated Hospital of USTC, Division of Life Sciences andMedicine, University of Science and Technology of China, 230001 Hefei, Anhui, China.3Dalian Medical University, 116000 Dalian, Liaoning, China.4Department of Neurosurgery,The Affiliated Chuzhou Hospital of Anhui Medical University, The First People’ s Hospital of Chuzhou, 239000 Chuzhou, Anhui, China.5Bengbu Medical College, 233000 Bengbu,Anhui, China 1Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China 2Department of Hepatobiliary Surgery, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China 3Key Laboratory of Intelligent Treatment and Life Support for Critical Diseases of Zhejiang, Wenzhou, Zhejiang, China 4Zhejiang Engineering Research Center for Hospital Emergency and Process Digitization, Wenzhou, Zhejiang, China Center for Biomedical Engineering, University of Science and Technology of China, Hefei, Anhui 230027, China Department of Electronic Science and Technology, University of Science and Technology of China, Hefei, Anhui 230027, China South China Agricultural University, Guangzhou, China Department of Hematology, Beijing Tongren Hospital, Capital Medical University, Beijing, China 1 School of Pharmaceutical Sciences, Guizhou Medical University, 2 State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, 3 College of Pharmacy, Guizhou University of Traditional Chinese Medicine Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, National Center for Neurological Disorders, National Clinical Center for Geriatric Disorders, National Key Laboratory for Medical Neurobiology, Institutes of Brain Science, Shanghai Key Laboratory of Brain Function and Regeneration, Institute of Neurosurgery, MOE Frontiers Center for Brain Science, Fudan University, Shanghai 200041, China 1Department of Opthalmology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China 2Department of Ophthalmology, Liyang Hospital of Chinese Medicine, Liyang, China School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang, 311121, China Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, Zhejiang, 311121, China School of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou, Zhejiang, 311121, China Department of Emergency, The Fourth Affiliated Hospital of Zhejiang University School of Medicine, Yiwu City, China Engineering Research Center of Cell & Therapeutic Antibody, Ministry of Education, and School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, PR China Department of Neurology, Shanxi Provincial People’s Hospital, Taiyuan 030012, Shanxi Province, China College of Veterinary Medicine, Hebei Agricultural University, No. 2596 Lekai South Street, Lianchi District, Baoding, 071000, People’s Republic of China Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, Jiangsu 221004, China School of Life Science and Technology, Inner Mongolia University of Science and Technology, China State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China CAS Center for Excellence in Biotic Interactions, University of Chinese Academy of Sciences, Beijing 100101, China Department of Clinical Laboratory, The Third Xiangya Hospital of Central South University, Changsha, R.P. China Key Laboratory of Plateau Mountain Animal Genetics, Breeding and Reproduction, Ministry of Education, Guizhou University, Guiyang, China College of Animal Science, Guizhou University, Guiyang, China College of Veterinary Medicine, South China Agricultural University, Guangzhou, China 1 Beijing Key Laboratory of Preclinical Research and Evaluation for Cardiovascular Implant Materials, Animal Experimental Center of Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, and National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, 102300 Beijing, China 2 Department of General Surgery & Pharmacy, The Affiliated Suqian First People's Hospital of Nanjing Medical University, 223800 Suqian, Jiangsu, China 3 Department of Colorectal Surgery, The First Affiliated Hospital of Nanjing Medical University, 210003 Nanjing, Jiangsu, China *Correspondence: taochen1381@njmu.edu.cn (Tao Chen); cuiyongchun@fuwai.com (Yongchun Cui) †These authors contributed equally. Tsinghua University College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China 1 School of Basic Medical Sciences, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, 2 The Second Affiliated Hospital, School of Medicine, The Chinese University of Hong Kong, Shenzhen & Longgang District People's Hospital of Shenzhen Guangdong 518172, 3 Department of Gastroenterology, Children's Medical Center of Anhui Medical University (Anhui Provincial Children’s Hospital), The Fifth Clinical College, Anhui Medical University, Hefei 230051, Anhui Department of Pharmacy, Ganzhou Women and Children’s Health Care Hospital, 341000, Ganzhou, Jiangxi, P.R. China Long-xing Xue and Song-feng Chen contributed equally to this work. Department of Neurology, The First Affiliated Hospital of Zhengzhou University, No. 1 JianShe Road, Zhengzhou, 450052, Henan Province, People’s Republic of China Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, No. 36, Sanhao Street, Heping District, Shenyang, Liaoning, People’s Republic of China Jingya Li and Ziao Liu have contributed equally to this work. School of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei, 230012, China Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, School of Public Health, Guizhou Medical University, Guiyang, 550025, Guizhou, China Department of Gastroenterology, Pudong New Area People’s Hospital, No. 490, Chuanhuan South Road, Pudong New Area, Shanghai, 201299, People’s Republic of China Special Medical Service Center, Zhujiang Hospital of Southern Medical University, No. 253, Middle Gongye Road, Haizhu District, Guangzhou, 510282, People’s Republic of China Anhui Academy of Chinese Medicine, Anhui University of Chinese Medicine, Hefei, 230012, People’s Republic of China Engineering Technology Research Center of Modernized Pharmaceutics, Anhui Education Department (AUCM), Hefei, 230012, Anhui, China School of Pharmacy, Institute of Pharmacokinetics, Anhui University of Chinese Medicine, Hefei, 230012, Anhui, China Anhui Genuine Chinese Medicinal Materials Quality Improvement Collaborative Innovation Center, Hefei, 230012, Anhui, China Anhui Province Key Laboratory of Pharmaceutical Preparation Technology and Application, Anhui University of Chinese Medicine, Hefei, 230012, Anhui, China Key Laboratory of Plant Resource Conservation and Germplasm Innovation in Mountainous Region (Ministry of Education), School of Pharmaceutical Sciences, Guizhou University, Guiyang, 550025, China Department of Endodontics, Changsha Stomatological Hospital, Hunan Province, Changsha, 410005, People’s Republic of China Department of Gastroenterology, Fuzong Clinical Medical College of Fujian Medical University/The 900th Hospital of the Joint Logistics Support Force Fuzhou, No. 156, West Second Ring Road, Fuzhou City, 350025, Fujian, People’s Republic of China Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, No. 218, Jixi Road, Shushan District, Hefei, 230022, China State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Guizhou Medical University, Guiyang, 550014, China Natural Products Research Center of Guizhou Province, Guiyang, 550014, China State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, 550014, China Natural Products Research Center of Guizhou Province, Guiyang, 550014, China School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang, 550025, China College of Life Sciences and Technology, Tarim University, Alar, Xinjiang, China School of Medicine, Jiangsu University, Zhenjiang, 212013, People’s Republic of China Postgraduate school, Medical school of Chinese PLA, Beijing 100853, China Department of Thoracic Surgery, the First Medical Center of Chinese PLA General Hospital, Beijing 100853, China These authors contributed equally to this work. Anhui Engineering Technology Research Center of Biochemical Pharmaceutical, Bengbu Medical College, Bengbu, Anhui, China The Research Center for Medical Genomics, Key Laboratory of Medical Cell Biology, Ministry of Education, School of Life Science, China Medical University, Shenyang, PR China College of Life Science, South-Central Minzu University, Wuhan, China These authors contributed equally to this work and share first authorship. National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, P. R. China Beijing National Laboratory for Molecular Sciences, Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China University of Chinese Academy of Sciences, Beijing 100190, China These authors contributed equally: Yanqin Zhang, Yanfang Deng, Yuewen Zhai. State Key Laboratory of Natural Medicines, Department of Biomedical Engineering, School of Engineering, China Pharmaceutical University, Nanjing, China Corresponding author at: Health Management Center, The First Dongguan Affiliated Hospital, Guangdong Medical University, No. 42 Jiaoping Road, Tangxia Town, Dongguan City, Guangdong Province 523000, China. College of Marine Life Science, Ocean University of China, 5# Yushan 10 Road, Qingdao 266003, PR China The Second Department of General Surgery, Cangzhou Central Hospital, No. 16 Xinhua West Road, Cangzhou, 061001, Hebei, China Key Laboratory of Animal Genetics, Breeding and Reproduction in The Plateau Mountainous Region, Ministry of Education, Guizhou University, Guiyang, 550025, China Key Laboratory of Animal Genetics, Breeding and Reproduction, Guiyang, 550025, China College of Animal Science, Guizhou University, Guiyang, 550025, China Shanxi Medical University, 56 Xinjian South Road, Taiyuan, Shanxi Province, China School of Basic Medicine, Dali University, Dali, Yunnan, 671000, China Department of Physiology, Basic Medical College of Nanchang University, Nanchang, P.R. China College of Economics and Management, Shanghai Ocean University, Shanghai, P.R. China College of Chemistry, Beijing Normal University, Beijing, China Key Laboratory of Environment and Female Reproductive Health, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen 518033, China Key Laboratory of Environment and Female Reproductive Health, West China School of Public Health & West China Fourth Hospital, Sichuan University, Chengdu 610041, China Chengdu Qingyang District for Disease Control and Prevention, Chengdu 610031, China Graduate School, Guangdong Medical University, Zhanjiang, Guangdong, 524023, China Department of Pediatrics, The Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, 524023, China College of Life Science, South-Central Minzu University, No. 182, Minyuan Road, Wuhan City, 430074, China Anhui Engineering Technology Research Center of Biochemical Pharmaceutical, Department of Pharmacy, Bengbu Medical University, 2600 Donghai Avenue, Bengbu, 233030, China Department of Ophthalmology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, PR China Department of Emergency, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, NanChang 330006, Jiangxi, China Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, Anhui 230022, China NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Anhui Medical University, Anhui 230022, China Key Laboratory of Population Health Across Life Cycle, Anhui Medical University, Ministry of Education of the People’s Republic of China, Anhui 230022, China School of Semiconductor and Physics, State Key Laboratory of Solid State Lighting, North University of China, Taiyuan, 030051, China State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming 650500, Yunnan, China School of Basic Medicine, Dali University, Dali 671000, Yunnan, China Jiangxi Province Key Laboratory of Pharmacology of Traditional Chinese Medicine, Gannan Medical University, Ganzhou 341000, China School of Pharmacy, Gannan Medical University, Ganzhou 341000, China Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases, Ministry of Education, Gannan Medical University, Ganzhou 341000, China Department of Preventive Medicine, School of Public Health, Fujian Medical University, Fuzhou, China Medical school of Nanjing University, Nanjing, China The Second People's Hospital of Hefei, Hefei Hospital Affiliated to Anhui Medical University, No. 246 of Heping Road, Yaohai District, Hefei, Anhui, China Institute of Food Safety, Chinese Academy of Inspection and Quarantine, Beijing 100176, China Key Laboratory of Food Quality and Safety for State Market Regulation, School of Pharmacy, China Medical University, Shenyang 110122, China College of Veterinary Medicine, Qingdao Agricultural University, Qingdao, 266109, PR China School of Leisure and Health, Guilin Tourism University, Guilin, 541006, China Corresponding author at: School of Leisure and Health, Guilin Tourism University, Guilin, 541006, China Department of Anesthesiology, Guangxi Medical University Cancer Hospital, Nanning, Guangxi 530021, China Department of Anesthesiology, The Second Affiliated Hospital of Chongqing Medical University, 400010 Chongqing, China Suisui Zhang and Lingyu Zhu contributed equally to this work and are joint first authors. Corresponding authors a College of Life Science, South-Central Minzu University, No. 182, Minyuan Road, Hongshan District, Wuhan City, China E-mail: guoxh@mail.scuec.edu.cn b Hubei Province Nutrition Chemicals Biosynthetic Engineering Technology Research Center, Wuhan 430073, China Department of Hepatobiliary and Pancreatic Surgery, China-Japan Union Hospital of Jilin University, Changchun, Jilin Province, China Department of Polymer Materials, Zhejiang Sci-Tech University, Hangzhou, 310018, China Department of Otorhinolaryngology Head and Neck, Shengjing Hospital of China Medical University, Liaoning Province, Shenyang, 110000, China The First Affiliated Hospital of Jinan University, Guangzhou, China The Second Affiliated Hospital of Bengbu Medical College, Bengbu, China Department of Dermatology, The Affiliated Hospital of Inner Mongolia Medical University, Xinhua Street, Hohhot, 010030, China Department of Thoracic Surgery, Esophagus and Mediastinum, Harbin Medical University Cancer Hospital, 150# Haping Road, Harbin, Heilongjiang, China Department of Reproductive Medicine, The First Affiliated Hospital of Henan University of Chinese Medicine, 19 Renmin Road, Zhengzhou, China Anhui Engineering Technology Research Center of Biochemical Pharmaceutical, Department of Pharmacy, Bengbu Medical College, 2600 Donghai Avenue, Bengbu, 233030, China Tianjin Key Laboratory of Agricultural Animal Breeding and Healthy Husbandry, College of Animal Science and Veterinary Medicine, Tianjin Agricultural University, Tianjin, 300384, China State Key Laboratory of Structure Analysis for Industrial Equipment, Department of Engineering Mechanics, Dalian University of Technology, Dalian, 116024, China Zhengqiang Wan and Cheng Li have contributed equally to this work. Binzhou Medical University, Shandong, China Department of Radiotherapy, the First Affiliated Hospital of Zhengzhou University, No. 1, East Jianshe Road, Zhengzhou, 450018, Henan Province, People’s Republic of China Institute of Neuroregeneration & Neurorehabilitation, Department of Neurosurgery, School of Basic Medicine, Qingdao University, 308 Ningxia Street, Qingdao, China Department of Biological Science, Jining Medical University, Rizhao, China Key Laboratory of Optoelectronic Technology and Systems, Ministry of Education & Key Disciplines Laboratory of Novel Micro-Nano Devices and System Technology, College of Optoelectronic Engineering, Chongqing University, Chongqing, 400044, China International R & D center of Micro-nano Systems and New Materials Technology, Chongqing University, Chongqing, 400044, China Department of Radiotherapy, Xuzhou Cancer Hospital, Xuzhou Third People’s Hospital, Xuzhou, 221005, People’s Republic of China Institute of Neuroregeneration & Neurorehabilitation, Department of Neurosurgery, Qingdao University, 308 Ningxia Street, Qingdao, 266071, China Department of Endocrinology and Metabolism, the First Affiliated Hospital of Zhengzhou University, No. 1, East Jianshe Road, Zhengzhou, 450000, Henan Province, People’s Republic of China Department of Obstetrics and Gynecology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China Xiu-Juan Zhao, Yi-Ran Zhang and Wen-Fei Bai have been contributed equally to this work. High-Throughput Molecular Drug Discovery Center, Tianjin International Joint Academy of BioMedicine, 300457, Tianjin, P. R. of China Tianjin Jena Pharmaceutical Technology Development Co., LTD, 300000, Tianjin, P. R. of China Guangxi Medical University, Nanning, 530021, China Center for Clinical Pharmacy, Cancer Center, Department of Pharmacy, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, Hangzhou, China Key Laboratory of Endocrine Gland Diseases of Zhejiang Province, Hangzhou, China School of Pharmacy, Jiangsu University, 301 Xuefu Road, Zhenjiang, 212013, China Department of Horticulture, College of Aburaihan, University of Tehran, Tehran, Iran School of Biology and Basic Medical Science, Soochow University, Suzhou, 215123, China Department of Dermatology, The Affiliated Huaian NO.1 People’s Hospital of Nanjing Medical University, No. 6, West Beijing Road, Huaiyin District, Huaian, 223300, Jiangsu, China Department of General Surgery, Wuxi 9th Hospital Affiliated to Soochow University, Wuxi City, Jiangsu Province, China Contribution: Formal analysis (equal), ​Investigation (equal), Writing - original draft (equal) Department of Dermatology, Hunan Engineering Research Center of Skin Health and Disease, Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South University, Changsha, Hunan, China National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China Anorectal Department, Linyi People’ s Hospital, Linyi, China Contribution: Conceptualization (lead), ​Investigation (lead), Writing - original draft (lead) Department of Pediatrics Laboratory, The Affiliated Wuxi Children's Hospital of Nanjing Medical University, Wuxi, China Department of Neurosurgery, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning, P.R. China Department of Orthopaedics, the Second Affiliated Hospital of Anhui Medical University, Hefei, China Department of Gastroenterology, The Third Xiangya Hospital of Central South University, Changsha 410013, China Department of Hematology, Tianjin Medical University General Hospital, Tianjin 300052, China Department of Obstetrics and Gynecology, The Second Hospital of Jilin University, Changchun, Jilin Province, China Contribution: Project administration, Writing - original draft Ethics Committee Office, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Heilongjiang, Harbin, China Department of Oral and Maxillofacial-Head Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology, Shanghai, China National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Research Unit of Oral and Maxillofacial Regenerative Medicine, Chinese Academy of Medical Sciences, Shanghai, China Department of Rehabilitation, School of Nursing, Jilin University, Changchun, China National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China Gastroenterology Department, The Number Two Hospital of Shanxi Medical University, Taiyuan, China Correspondence Feng Hong, Gastroenterology Department, The Number Two Hospital of Shanxi Medical University, No. 382, Wuyi Road, Taiyuan, Shanxi 030000, China. Stomatological Hospital, Southern Medical University, Guangzhou, Guangdong, China Department of Medical Genetics, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China Department of Urology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China Department of Anesthesiology, the 2nd affiliated hospital, Jiangxi Medical College, Nanchang University, Nanchang, China Hypertension Center, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, Gansu, China Department of Prosthodontics, Hebei Key Laboratory of Stomatology, Hebei Clinical Research Center for Oral Diseases, School and Hospital of Stomatology, Hebei Medical University, Shijiazhuang, PR China Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan, China Department of Dermatology, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Infection and Immunity, Chongqing 400014, China Lab for Bone Metabolism, Xi'an Key Laboratory of Special Medicine and Health Engineering, Key Lab for Space Biosciences and Biotechnology, Research Center for Special Medicine and Health Systems Engineering, NPU-UAB Joint Laboratory for Bone Metabolism, School of Life Sciences, Northwestern Polytechnical University, Xi'an, China Biological Effects and Technology Division, Institute for Hygiene of Ordnance Industry, Xi'an, China The Key Laboratory of Molecular Epigenetics of Ministry of Education, Institute of Genetics and Cytology, Northeast Normal University, Changchun, Jilin, China State Key Laboratory of Silicon Materials, School of Materials Science and Engineering, Zhejiang University, Hangzhou, 310058 P.R. China ZJU-Hangzhou Global Scientific and Technological Innovation Center, Hangzhou, 311200 P. R. China Department of General Surgery, Anhui No.2 Provincial People's Hospital, Hefei, China Anhui No.2 Provincial People's Hospital Clinical College of Anhui Medical University, Hefei, China Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Luqiao, Zhejiang 318050, China CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing, 100190 P. R. China University of Chinese Academy of Sciences, Beijing, 100049 P. R. China Multiple Sclerosis Center, Department of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China Mental and Neurological Diseases Research Center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China Department of Orthopaedics, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China Hunan Key Laboratory of Tumor Models and Individualized Medicine, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China Shenzhen Research Institute of Central South University, Guangdong, China College of Chemistry and Molecular Sciences, Wuhan University, 299 Bayi Road, Wuhan, Hubei Province, 430072 China College of Chemistry and Chemical Engineering, Hubei University, Wuhan, Hubei, 430062 China Institute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University, Chengdu, 610031 China Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, 610031 China Dermatology, The Second Hospital of Hebei Medical University, Shijiazhuang Hebei, China Department of Nutrition, School of Public Health, Sun Yat-sen University (Northern Campus), Guangzhou, Guangdong Province, 510080 P.R. China Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Guangzhou, Guangdong Province, 510080 P.R. China Department of thoracic surgery, Affiliated Hospital of Southwest Medical University, Luzhou, China Correspondence Jiangtao Pu, Department of Thoracic Surgery, Affiliated Hospital of Southwest Medical University, No. 25 Taiping St, Luzhou, 646000, Sichuan, China Department of Biotechnology, College of Life Science and Chemistry, Beijing University of Technology, Chaoyang, Beijing, China School of Horticulture and Plant Protection, Yangzhou University, Yangzhou, China Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China Department of Burn and Plastic Surgery, General Hospital of Southern Theater Command, PLA, Guangzhou, China The Key Laboratory of Trauma Treatment & Tissue Repair of Tropical Area of Chinese PLA, Guangzhou, China These two authors contributed equally to this work. Department of Toxicology, School of Public Health, Guangxi Medical University, Nanning 530021, Guangxi, China Guangxi Key Laboratory of Environment and Health Research, Guangxi Medical University, Nanning 530021, Guangxi, China Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases, Guangxi Medical University, Nanning 530021, Guangxi, China School of Pharmacy, Xi'an Jiaotong University, Xi'an, PR China Pharmacy Department, Shenzhen Luohu People’s Hospital, Youyi Road No.47, Shenzhen 518000, China School of Pharmacy, China Pharmaceutical University, Tongjiaxiang #24, Nanjing 210009, China Shaanxi Key Laboratory of Chemical Additives for Industry, Xi’an Key Laboratory of Advanced Performance Materials and Polymers, College of Chemistry and Chemical Engineering, Shaanxi University of Science and Technology, Xuefu Road, Weiyang District, Xi’an 710021 PR China Department of Cardiothoracic Surgery, The First Affiliated Hospital of Chongqing Medical University, 400016 Chongqing, China. College of Food Science and Engineering, Nanjing University of Finance and Economics/Collaborative Innovation Center for Modern Grain Circulation and Safety, Nanjing, 210023, People's Republic of China Department of Cardiology, Yijishan Hospital of Wannan Medical College, Wuhu, China Key Laboratory of Non-coding RNA Transformation Research of Anhui Higher Education Institution, Wannan Medical College, 241002 Wuhu, China Wenzhou Municipal Key Laboratory of Pediatric Pharmacy, Department of Pharmacy, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China School of Pharmaceutical Science, Zhejiang Chinese Medical University, 260 Baichuan Road, Hangzhou 311400, PR China Department of Neurology, Shengjing Hospital of China Medical University, No. 36, Sanhao Street, Shenyang 110004, China Department of Interventional Therapy, The First Affiliated Hospital of Dalian Medical University, Dalian, China Department of Environmental Engineering, Zhejiang University, Hangzhou 310029, PR China Key Laboratory of Water Pollution Control and Environmental Safety of Zhejiang Province, Hangzhou 310020, PR China Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Wenhua Road, Jinan 250012, PR China College of Basic Medical Science, China Three Gorges University, Yichang, China Third-grade Pharmacological Laboratory on Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine, College of Medicine and Health Sciences, China Three Gorges University, Yichang, China School of Pharmacy, Xi'an Jiaotong University, No. 76 Western Yanta Road, Xi'an City, Shaanxi Province 710061, PR China Department of Urology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China The First Affiliated Hospital of Hebei University of Chinese Medicine, China Hebei University of Chinese Medicine, China School of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou, 30018, China Fisheries College, Jimei University, Xiamen 361021, China Engineering Research Center of the Modern Industry Technology for Eel, Ministry of Education of PRC, Xiamen 361021, China State Key Laboratory of Mariculture Breeding, Fisheries College of Jimei University, Xiamen 361021, China Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China Department of Urology, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, China School of Medicine, Tongji University, Shanghai 200092, China State Key Laboratory of Structure Analysis for Industrial Equipment, Department of Engineering Mechanics, Dalian University of Technology, Dalian 116024, China Medical University Jinzhou City, Liaoning Province 121000, China Department of Otolaryngology, Head & Neck Surgery, The Second Hospital of Hebei Medical University, China Department of Radiation Oncology, The First Affiliated Hospital of Xi’an Jiaotong University, No. 277, Yanta West Road, Xi’an, Shaanxi, 710061, China College of Horticulure and Plant Protection, Henan University of Science and Technology, Luoyang 471023, China Henan Engineering Technology Research Center of Quality Regulation and Controlling of Horticultural Plants, College of Horticulture and Plant Protection, Henan University of Science and Technology, Luoyang, 471023, Henan Province, China Department of Orthopedics, The First Affiliated Hospital of Zhengzhou University, No. 1, Jianshe East Road, Zhengzhou, China Key Laboratory of Engineering Biology for Low-carbon Manufacturing, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China National Technology Innovation Center of Synthetic Biology, Tianjin, China School of Materials Science and Engineering, Shandong University of Science and Technology, Qingdao 266590, China Department of Implantology & Tissue Engineering and Regeneration, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, Shandong 250012, China Macau University of Science and Technology, Faculty of Chinese Medicine, Taipa, Macao, 999078, China Shenzhen Traditional Chinese Medicine Hospital, Department of Liver Disease, Shenzhen, 518033, China These authors contributed equally to this study and are co-first authors. State Key Laboratory of Food Science & Resources, Nanchang University, Jiangxi, 330047, PR China School of Food Science & Technology, Nanchang University, Jiangxi, 330006, PR China Jiangsu Provincial Key Laboratory of Drug Metabolism and Pharmacokinetics, Key Laboratory of Natural Medicines,China Pharmaceutical University, Tongjiaxiang 24, Nanjing 210009, P.R. China Academy of Medical Sciences, Tianjian Laboratory of Advanced Biomedical Sciences, Zhengzhou University, Zhengzhou, China Department of Pharmacology, School of Basic Medical Sciences, Open and Key Laboratory for Pharmacogenomics at Henan Universities, Zhengzhou University, Zhengzhou, China Experimental Center of Clinical Research, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, China School of Pharmacy, Anhui University of Chinese Medicine, Hefei, China co-first authors. Department of Physiology, School of Medicine, Yanbian University, Yanji 133-002, China Department of Ultrasound, Zhongnan Hospital of Wuhan University, Wuhan, China Department of Dermatology, Hunan Engineering Research Center of Skin Health and Disease, Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Central South University, Changsha, Hunan 410008, China School of Pharmacy, Gannan Medical University, Ganzhou, 341000, China Anhui University of Chinese Medicine, Hefei, 230012, Anhui, China Engineering Technology Research Center of Modernized Pharmaceutics, Anhui Education Department (AUCM), Hefei, 230012, Anhui, China School of Pharmacy, Institute of Pharmacokinetics, Anhui University of Chinese Medicine, Hefei, 230012, Anhui, China Anhui Academy of Chinese Medicine, Anhui Genuine Chinese Medicinal Materials Quality Improvement Collaborative Innovation Center, Hefei, 230012, Anhui, China Junying Li and Xiaoxiao Shan made equal contributions to this paper and should be regarded as co-first authors. Key Laboratory for Ultrafine Materials of Ministry of Education, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Engineering Research Center for Biomedical Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai, 200237, PR China School of Medical Technology and Information Engineering, Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang, People's Republic of China School of Medical Technology and Information Engineering, Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang, China Department of Pharmacy, The Second Xiangya Hospital of Central South University, Changsha, 410011, China Hunan Provincial Engineering Research Center of Translational Medical and Innovative Drug, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, China Corresponding author. Department of Pharmacy, the Second Xiangya Hospital of Central South University, Changsha, 410011, China. Hebei Provincial Key Laboratory of Molecular Biophysics, Hebei University of Technology, Tianjin 300401, China Institute of Biophysics, School of Sciences, Hebei University of Technology, Tianjin 300401, China State Key Laboratory of Reliability and Intelligence of Electrical Equipment, Hebei University of Technology, Tianjin 300401, China School of Materials Science and Engineering, Hebei University of Technology, Tianjin 300401, China School of Electrical Engineering, Hebei University of Technology, Tianjin 300401, China State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China Department of Pharmaceutics, School of Pharmacy, Jilin University, No. 1266, Fujin Road, Changchun 130021, China Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, International Innovation Center for Forest Chemicals and Materials, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China Nanjing University of Chinese Medicine, Nanjing, 210023, China Huai'an Maternal and Child Health-Care Center, Huai'an, 223000, China School of Pharmacy, Anhui Medical University, Hefei, Anhui, PR China Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, Anhui, PR China State Key Laboratory of Natural Medicines, School of Basic Medical and Clinical Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu, PR China Department of Neurology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China Beijing Key Laboratory of Drug Delivery and Novel Formulation, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China Beijing Tongren Hospital, China Capital Medical University, Beijing, 100730, China Colorectal and Anal Surgery, The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, No 71 Baoshan North Road, Guiyang 550001, China School of Science, Xihua University, Chengdu, 610039, China