- accession:NM_145893
- 基因别名:RBFOX1
- 基因描述:Homo sapiens RNA binding protein, fox-1 homolog (C. elegans) 1 (RBFOX1), transcript variant 3, mRNA.
- 载体: 现货载体
- CDS区长度:1188
- 翻译后氨基酸长度:395
- TranscriptVariant:This variant (3), also known as beta, has an alternate exon in the 3' coding region, compared to variant 1. This results in a shorter isoform (3) with an alternate C-terminus, compared to isoform 1.
- 基因简介:The Fox-1 family of RNA-binding proteins is evolutionarily conserved, and regulates tissue-specific alternative splicing in metazoa. Fox-1 recognizes a (U)GCAUG stretch in regulated exons or in flanking introns. The protein binds to the C-terminus of ataxin-2 and may contribute to the restricted pathology of spinocerebellar ataxia type 2 (SCA2). Ataxin-2 is the product of the SCA2 gene which causes familial neurodegenerative diseases. Fox-1 and ataxin-2 are both localized in the trans-Golgi network. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
- 载体信息:自有图片地址
- 规格:10ul 质粒
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