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- accession：NM_172218
- 基因别名：SPAG1
- 基因描述：Homo sapiens sperm associated antigen 1 (SPAG1), transcript variant 2, mRNA.
- 载体：现货载体
- CDS区长度：2781
- 翻译后氨基酸长度：926
- TranscriptVariant：This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
- 基因简介：The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm agglutinating antibodies from an infertile woman. Furthermore, immunization of female rats with the recombinant human protein reduced fertility. This protein localizes to the plasma membrane of germ cells in the testis and to the post-acrosomal plasma membrane of mature spermatozoa. Recombinant polypeptide binds GTP and exhibits GTPase activity. Thus, this protein may regulate GTP signal transduction pathways involved in spermatogenesis and fertilization. Two transcript variants of this gene encode the same protein. [provided by RefSeq, Jul 2008]
- 规格：10ul 质粒
CDS区参考序列： 点击查看序列翻译后氨基酸参数序列： 点击查看序列
