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- accession：NM_001160099
- 基因别名：Cldn10
- 基因描述：Mus musculus claudin 10 (Cldn10), transcript variant b_v1, mRNA.
- 载体：现货载体
- CDS区长度：588
- 翻译后氨基酸长度：195
- TranscriptVariant：This variant (b_v1) differs in the 5' UTR and 5' coding region, representing use of an alternate promoter, and lacks an alternate in-frame exon in the 3' coding region, compared to variant a. The resulting isoform (b_i1) has a longer and distinct N-terminus and lacks an internal segment including the entire fourth transmembrane region, compared to isoform a. This variant is expressed in all tissues tested, with lowest expression in liver and highest expression in kidney.
- 基因简介：This intronless gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight unction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Six alternatively spliced transcript variants have been identified, which encode different isoforms with distinct electric charge of the first extracellular loop and with or without the fourth transmembrane region. These isoforms exhibit distinct localization and function in paracellular anion or cation permeability. [provided by RefSeq, Aug 2010]
- 规格：10ul 质粒
CDS区参考序列： 点击查看序列翻译后氨基酸参数序列： 点击查看序列
