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人 APOB (NM_000384) cDNA克隆
人 APOB (NM_000384) cDNA克隆
  • 商品货号:FC151657
  • 已售 3 件 | 评价 0 人次 | 关注度 295
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    • accession:NM_000384
    • 基因别名:APOB
    • 基因描述:Homo sapiens apolipoprotein B (APOB), mRNA.
    • 载体:现货载体
    • CDS区长度:13692
    • 翻译后氨基酸长度:4563
    • 基因简介:This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100: the former is synthesized exclusively in the gut and the latter in the liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination. Mutations in this gene or its regulatory region cause hypobetalipoproteinemia, normotriglyceridemic hypobetalipoproteinemia, and hypercholesterolemia due to ligand-defective apoB, diseases affecting plasma cholesterol and apoB levels. [provided by RefSeq, Jul 2008]
    • 规格:10ul 质粒
    CDS区参考序列: 点击查看序列
    翻译后氨基酸参数序列: 点击查看序列