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人ACE2(NM_021804)ORF克隆 CALU-3细胞 vero E6非洲绿猴肾细胞
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人 HSPG2 (NM_005529) cDNA克隆
人 HSPG2 (NM_005529) cDNA克隆
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    • accession：NM_005529
    • 基因别名：HSPG2
    • 基因描述：Homo sapiens heparan sulfate proteoglycan 2 (HSPG2), mRNA.
    • 载体：现货载体
    • CDS区长度：13176
    • 翻译后氨基酸长度：4391
    • 基因简介：This gene encodes the perlecan protein, which consists of a core protein to which three long chains of glycosaminoglycans (heparan sulfate or chondroitin sulfate) are attached. The perlecan protein is a large multidomain proteoglycan that binds to and cross-links many extracellular matrix components and cell-surface molecules. It has been shown that this protein interacts with laminin, prolargin, collagen type IV, FGFBP1, FBLN2, FGF7 and Transthyretin, etc. and plays essential roles in multiple biological activities. Perlecan is a key component of the vascular extracellular matrix, where it helps to maintain the endothelial barrier function. It is a potent inhibitor of smooth muscle cell proliferation and is thus thought to help maintain vascular homeostasis. It can also promote growth factor (e.g., FGF2) activity and thus stimulate endothelial growth and re-generation. It is a major component of basement membranes, where it is involved in the stabilization of other molecules as well as being involved with glomerular permeability to macromolecules and cell adhesion. Mutations in this gene cause Schwartz-Jampel syndrome type 1, Silverman-Handmaker type of dyssegmental dysplasia, and Tardive dyskinesia.[provided by RefSeq, Mar 2010]
    • 规格：10ul 质粒
    CDS区参考序列： 点击查看序列
    翻译后氨基酸参数序列： 点击查看序列
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