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- accession：NM_177982
- 基因别名：Hap1
- 基因描述：Rattus norvegicus huntingtin-associated protein 1 (Hap1), transcript variant 2, mRNA.
- 载体：现货载体
- CDS区长度：1890
- 翻译后氨基酸长度：629
- TranscriptVariant：This variant (2) lacks a segment in the 3' coding region that causes a frameshift, and lacks a segment in the 3' UTR, compared to variant 1. The encoded protein (isoform B) is longer and has a distinct C-terminus, compared to isoform A.
- 基因简介：Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that is homologous to the human huntingtin-associated protein 1. The human protein interacts with huntingtin, with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), and with a hepatocyte growth factor-regulated tyrosine kinase substrate. The interactions with cytoskeletal proteins and a kinase substrate suggest a role for this protein in vesicular trafficking or organelle transport. Two transcripts encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
- 规格：10ul 质粒
CDS区参考序列： 点击查看序列翻译后氨基酸参数序列： 点击查看序列
