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- accession：NM_001024094
- 基因别名：NR3C1
- 基因描述：Homo sapiens nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) (NR3C1), transcript variant 7, mRNA.
- 载体： 现货载体
- CDS区长度：2337
- 翻译后氨基酸长度：778
- TranscriptVariant：This variant (7) uses an alternate in-frame donor splice site at one of the coding exons compared to variant 1. This results in an isoform (gamma) that is 1 aa longer than isoform alpha. The insertion of an additional amino acid (arginine) in the DNA binding domain has been reported to decrease transcriptional activation by the glucocorticoid receptor (PMID:10566686).
- 基因简介：This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011]
- 载体信息：自有图片地址
- 规格：10ul 质粒
CDS区参考序列： 点击查看序列翻译后氨基酸参数序列： 点击查看序列
