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- accession：NM_001111057
- 基因别名：Adarb1
- 基因描述：Rattus norvegicus adenosine deaminase, RNA-specific, B1 (Adarb1), transcript variant 4, mRNA.
- 载体：现货载体
- CDS区长度：2034
- 翻译后氨基酸长度：677
- TranscriptVariant：This variant (4, also referred to as 2e) results from an auto RNA editing event (AA->AI) in the intronic sequence that creates a novel acceptor splice site, splicing to which inserts 47 nt into the coding region causing a frame-shift, compared to transcript variant 2. Translation initiation from the upstream AUG will result in a very short protein of 82 aa. However, studies reported in PMID:10331393 show that leaky translation initiation from an in-frame, downstream AUG allows some protein expression, and that this isoform (3) exhibits RNA editing activity. Isoform 4 is 24 aa shorter at the N-terminus compared to isoform 2.
- 基因简介：This gene encodes a double-stranded-RNA-specific adenosine deaminase that is involved in editing pre-mRNAs by site-specific conversion of adenosine (A) to inosine (I). Substrates for this enzyme include ionotropic glutamate receptors (GluR2-6) and serotonin receptor (5HT2C). Studies in rodents have shown that this protein can modify its own pre-mRNA by A->I editing to create a novel acceptor splice site, alternative splicing to which results in down regulation of its protein expression. Additional splicing events result in transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
- 规格：10ul 质粒
CDS区参考序列： 点击查看序列翻译后氨基酸参数序列： 点击查看序列
