- 商品货号:F111734
- accession:NM_001167
- 基因别名:XIAP
- 基因描述:Homo sapiens X-linked inhibitor of apoptosis (XIAP), transcript variant 1, mRNA.
- 载体: 现货载体
- CDS区长度:1494
- 翻译后氨基酸长度:497
- TranscriptVariant:This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same protein.
- 基因简介:This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.[provided by RefSeq, Feb 2011]
- 载体信息:自有图片地址
- 规格:10ul 质粒
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