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人 DSP (NM_001008844) cDNA克隆
人 DSP (NM_001008844) cDNA克隆
¥5500元
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  • 商品货号:G134612
  • accession:NM_001008844
  • 基因别名:DSP
  • 基因描述:Homo sapiens desmoplakin (DSP), transcript variant 2, mRNA.
  • 载体:pDONR223
  • CDS区长度:6819
  • 翻译后氨基酸长度:2272
  • TranscriptVariant:This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The resulting isoform (II) has a shorter C-terminus, compared to isoform I.
  • 基因简介:Desmosomes are intercellular junctions that tightly link adjacent cells. Desmoplakin is an obligate component of functional desmosomes that anchors intermediate filaments to desmosomal plaques. The N-terminus of desmoplakin is required for localization to the desmosome and interacts with the N-terminal region of plakophilin 1 and plakoglobin. The C-terminus of desmoplakin binds with intermediate filaments. In the mid-region of desmoplakin, a coiled-coiled rod domain is responsible for homodimerization. Mutations in this gene are the cause of several cardiomyopathies and keratodermas as well as the autoimmune disease paraneoplastic pemphigus. [provided by RefSeq, Jul 2008]
  • 规格:10ul 质粒
CDS区参考序列: 点击查看序列
翻译后氨基酸参数序列: 点击查看序列