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- accession：NM_004406
- 基因别名：DMBT1
- 基因描述：Homo sapiens deleted in malignant brain tumors 1 (DMBT1), transcript variant 1, mRNA.
- 载体：现货载体
- CDS区长度：5358
- 翻译后氨基酸长度：1785
- TranscriptVariant：This transcript variant (1) is missing multiple exons. The resulting protein lacks the C-terminal half of SIDs 3, 5, and 6, the N-terminal part of SID 7, and SRCR domains 4, 5, 6, and 7 as well as one SID and one SRCR domain between SIDs 9 and 11.
- 基因简介：Loss of sequences from human chromosome 10q has been associated with the progression of human cancers. The gene DMBT1 was originally isolated based on its deletion in a medulloblastoma cell line. DMBT1 is expressed with transcripts of 6.0, 7.5, and 8.0 kb in fetal lung and with one transcript of 8.0 kb in adult lung, although the 7.5 kb transcript has not been characterized. The DMBT1 protein is a glycoprotein containing multiple scavenger receptor cysteine-rich (SRCR) domains separated by SRCR-interspersed domains (SID). Transcript variant 2 (8.0 kb) has been shown to bind surfactant protein D independently of carbohydrate recognition. This indicates that DMBT1 may not be a classical tumor supressor gene, but rather play a role in the interaction of tumor cells and the immune system. [provided by RefSeq, Jul 2008]
- 规格：10ul 质粒
CDS区参考序列： 点击查看序列翻译后氨基酸参数序列： 点击查看序列
