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- accession：NM_001242502
- 基因别名：DIO2
- 基因描述：Homo sapiens deiodinase, iodothyronine, type II (DIO2), transcript variant 4, mRNA.
- 载体：现货载体
- CDS区长度：441
- 翻译后氨基酸长度：146
- TranscriptVariant：This variant (4) differs in the 5' UTR and includes two alternate exons in the coding region with the latter resulting in a frameshift, compared to variant 1. It encodes isoform c, which has a shorter and distinct C-terminus, compared to isoform a.
- 基因简介：The protein encoded by this gene belongs to the iodothyronine deiodinase family. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3). It is highly expressed in the thyroid, and may contribute significantly to the relative increase in thyroidal T3 production in patients with Graves disease and thyroid adenomas. This protein contains selenocysteine (Sec) residues encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
- 规格：10ul 质粒
CDS区参考序列： 点击查看序列翻译后氨基酸参数序列： 点击查看序列
