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- accession：NM_001177704
- 基因别名：FREM1
- 基因描述：Homo sapiens FRAS1 related extracellular matrix 1 (FREM1), transcript variant 2, mRNA.
- 载体：现货载体
- CDS区长度：2148
- 翻译后氨基酸长度：715
- TranscriptVariant：This variant (2) lacks many of the 5' coding exons found in variant 1 and has a different 5' UTR and 5' CDS. The resulting protein, (isoform 2, also known as Toll-like/interleukin-1 receptor regulator, TILRR) has a different N-terminus and is shorter than isoform 1. This isoform has been shown to associate with the extracellular domain of interleukin-1 receptors and magnify inflammatory responses regulated by nuclear factor kappa B.
- 基因简介：This gene encodes a basement membrane protein that may play a role in craniofacial and renal development. Mutations in this gene have been associated with bifid nose with or without anorectal and renal anomalies. Alternatively spliced transcript variants encoding different isoforms have been described. PubMed ID 19940113 describes one such variant that initiates transcription within a distinct, internal exon; the resulting shorter isoform (named Toll-like/interleukin-1 receptor regulator, TILRR) is suggested to be a co-receptor of the interleukin 1 receptor family and may regulate receptor function and Toll-like receptor/interleukin 1 receptor signal transduction, contributing to the control of inflammatory response activation. [provided by RefSeq, Apr 2011]
- 规格：10ul 质粒
CDS区参考序列： 点击查看序列翻译后氨基酸参数序列： 点击查看序列
