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- 商品货号：G131723
- accession：NM_001077507
- 基因别名：Gnas
- 基因描述：Mus musculus GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus (Gnas), transcript variant 5, mRNA.
- 载体：现货载体
- CDS区长度：3360
- 翻译后氨基酸长度：1119
- TranscriptVariant：This variant (5, also known as GNASXL) is paternally expressed. It has an alternate 5' exon, lacks an internal exon and uses an alternate splice site in the coding region, as compared to variant 7. It encodes isoform f, also known as XLas, which has a distinct and much longer N-terminus, lacks an internal segment and has two amino acids different, as compared to isoform GNASL. Isoform f is neuroendocrine-specific G-protein alpha subunit.
- 基因简介：This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and the 5' exons. Some transcripts contain a differentially methylated region (DMR) at their 5' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. This gene has an antisense transcript. One of the transcripts produced from this locus, and the antisense transcript, are both paternally expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants have been found for this gene, but the full-length nature and/or biological validity of some variants have not been determined. [provided by RefSeq, Apr 2009]
- 规格：10ul 质粒
CDS区参考序列： 点击查看序列翻译后氨基酸参数序列： 点击查看序列
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