• 商品货号：F109127

• accession：NM_022039
• 基因别名：FBXW4
• 基因描述：Homo sapiens F-box and WD repeat domain containing 4 (FBXW4), mRNA.
• 载体： 现货载体
• CDS区长度：1239
• 翻译后氨基酸长度：412
• 基因简介：This gene is a member of the F-box/WD-40 gene family, which recruit specific target proteins through their WD-40 protein-protein binding domains for ubiquitin mediated degradation. In mouse, a highly similar protein is thought to be responsible for maintaining the apical ectodermal ridge of developing limb buds; disruption of the mouse gene results in the absence of central digits, underdeveloped or absent metacarpal/metatarsal bones and syndactyly. This phenotype is remarkably similar to split hand-split foot malformation in humans, a clinically heterogeneous condition with a variety of modes of transmission. An autosomal recessive form has been mapped to the chromosomal region where this gene is located, and complex rearrangements involving duplications of this gene and others have been associated with the condition. A pseudogene of this locus has been mapped to one of the introns of the BCR gene on chromosome 22. [provided by RefSeq, Jul 2008]
• 载体信息：自有图片地址
• 规格：10ul 质粒

CDS区参考序列： 点击查看序列

ATGGCGGCGGCGGCCGGGGAGGAGGAGGAGGAGGAGGAGGCGGCTCGGGAGTCGGCTGCCCGCCCGGCCGCGGGGCCTGCGCTCTGGCGCCTGCCGGAGGAGCTGCTGCTGCTCATCTGCTCCTACCTGGACATGCGGGCCCTCGGCCGCCTGGCCCAGGTGTGCCGCTGGCTGCGGCGCTTCACCAGCTGCGATCTGCTCTGGCGCCGGATAGCCCGGGCCTCGCTCAACTCCGGCTTCACGCGGCTCGGCACCGACCTGATGACCAGTGTCCCAGTGAAGGAACGAGTGAAGGTGTCTCAGAACTGGAGACTGGGGCGCTGCCGAGAGGGGATTCTGCTGAAGTGGAGATGCAGTCAGATGCCCTGGATGCAGCTAGAGGATGATTCTCTGTACATATCCCAGGCTAATTTCATCCTGGCCTACCAGTTCCGTCCAGATGGTGCCAGCTTGAATCGTCGGCCTCTGGGAGTCTTTGCTGGGCATGATGAGGACGTTTGCCACTTTGTGCTGGCCAACTCGCATATTGTTAGTGCAGGAGGGGATGGGAAGATTGGCATTCATAAGATTCACAGCACCTTCACTGTCAAGTACTCGGCTCATGAACAGGAGGTGAACTGTGTGGATTGCAAAGGGGGCATCATTGTGAGTGGCTCCAGGGACAGGACGGCCAAGGTGTGGCCTTTGGCCTCAGGCCGGCTGGGGCAGTGCTTACACACCATCCAGACTGAAGACCGAGTCTGGTCCATTGCTATCAGCCCATTACTCAGCTCTTTTGTGACAGGGACGGCTTGTTGCGGGCACTTCTCACCCCTGAGAATCTGGGACCTCAACAGTGGGCAGCTGATGACACACTTGGGCAGTGACTTTCCCCCAGGGGCTGGGGTGCTGGATGTCATGTATGAGTCCCCTTTCACACTGCTGTCCTGTGGCTATGACACCTATGTTCGCTACTGGGACCTCCGCACCAGCGTCCGGAAATGTGTCATGGAGTGGGAGGAGCCCCACGACAGCACCCTGTACTGCCTGCAGACAGATGGCAACCACCTGCTGGCCACAGGTTCCTCCTACTACGGTGTTGTACGGCTGTGGGACCGGCGTCAAAGGGCCTGCCTGCACGCCTTCCCGCTGACGTCGACTCCCCTCAGCAGCCCTGTGTACTGCCTGCGTCTCACCACCAAGCATCTCTATGCTGCCCTGTCTTACAACCTCCACGTCCTGGATTTTCAAAACCCATGA

翻译后氨基酸参数序列： 点击查看序列

ATGGCGGCGGCGGCCGGGGAGGAGGAGGAGGAGGAGGAGGCGGCTCGGGAGTCGGCTGCCCGCCCGGCCGCGGGGCCTGCGCTCTGGCGCCTGCCGGAGGAGCTGCTGCTGCTCATCTGCTCCTACCTGGACATGCGGGCCCTCGGCCGCCTGGCCCAGGTGTGCCGCTGGCTGCGGCGCTTCACCAGCTGCGATCTGCTCTGGCGCCGGATAGCCCGGGCCTCGCTCAACTCCGGCTTCACGCGGCTCGGCACCGACCTGATGACCAGTGTCCCAGTGAAGGAACGAGTGAAGGTGTCTCAGAACTGGAGACTGGGGCGCTGCCGAGAGGGGATTCTGCTGAAGTGGAGATGCAGTCAGATGCCCTGGATGCAGCTAGAGGATGATTCTCTGTACATATCCCAGGCTAATTTCATCCTGGCCTACCAGTTCCGTCCAGATGGTGCCAGCTTGAATCGTCGGCCTCTGGGAGTCTTTGCTGGGCATGATGAGGACGTTTGCCACTTTGTGCTGGCCAACTCGCATATTGTTAGTGCAGGAGGGGATGGGAAGATTGGCATTCATAAGATTCACAGCACCTTCACTGTCAAGTACTCGGCTCATGAACAGGAGGTGAACTGTGTGGATTGCAAAGGGGGCATCATTGTGAGTGGCTCCAGGGACAGGACGGCCAAGGTGTGGCCTTTGGCCTCAGGCCGGCTGGGGCAGTGCTTACACACCATCCAGACTGAAGACCGAGTCTGGTCCATTGCTATCAGCCCATTACTCAGCTCTTTTGTGACAGGGACGGCTTGTTGCGGGCACTTCTCACCCCTGAGAATCTGGGACCTCAACAGTGGGCAGCTGATGACACACTTGGGCAGTGACTTTCCCCCAGGGGCTGGGGTGCTGGATGTCATGTATGAGTCCCCTTTCACACTGCTGTCCTGTGGCTATGACACCTATGTTCGCTACTGGGACCTCCGCACCAGCGTCCGGAAATGTGTCATGGAGTGGGAGGAGCCCCACGACAGCACCCTGTACTGCCTGCAGACAGATGGCAACCACCTGCTGGCCACAGGTTCCTCCTACTACGGTGTTGTACGGCTGTGGGACCGGCGTCAAAGGGCCTGCCTGCACGCCTTCCCGCTGACGTCGACTCCCCTCAGCAGCCCTGTGTACTGCCTGCGTCTCACCACCAAGCATCTCTATGCTGCCCTGTCTTACAACCTCCACGTCCTGGATTTTCAAAACCCATGA