×
![]()
- accession：NM_014454
- 基因别名：SESN1
- 基因描述：Homo sapiens sestrin 1 (SESN1), transcript variant 1, mRNA.
- 载体：现货载体
- CDS区长度：1656
- 翻译后氨基酸长度：551
- TranscriptVariant：This variant (1) represents the longest transcript and encodes the longest isoform (1).
- 基因简介：This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
- 规格：10ul 质粒
CDS区参考序列： 点击查看序列翻译后氨基酸参数序列： 点击查看序列
