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- accession：NM_003361
- 基因别名：UMOD
- 基因描述：Homo sapiens uromodulin (UMOD), transcript variant 1, mRNA.
- 载体：现货载体
- CDS区长度：1923
- 翻译后氨基酸长度：640
- TranscriptVariant：This variant (1) encodes the shorter isoform (a). Both variants 1 and 2 encode the same isoform.
- 基因简介：The protein encoded by this gene is the most abundant protein in mammalian urine under physiological conditions. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. This protein may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of this protein in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the renal disorders medullary cystic kidney disease-2 (MCKD2), glomerulocystic kidney disease with hyperuricemia and isosthenuria (GCKDHI), and familial juvenile hyperuricemic nephropathy (FJHN). Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2013]
- 规格：10ul 质粒
CDS区参考序列： 点击查看序列翻译后氨基酸参数序列： 点击查看序列
