- 商品货号:G118402
- accession:NM_002648
- 基因别名:PIM1
- 基因描述:Homo sapiens pim-1 oncogene (PIM1), transcript variant 1, mRNA.
- 载体:现货载体
- CDS区长度:942
- 翻译后氨基酸长度:313
- TranscriptVariant:This variant (1) encodes two isoforms resulting from the use of alternate in-frame, translation initiation codons. This RefSeq represents the shorter isoform (2, also known as Pim-1S) derived from the use of a downstream AUG (at nt 431-433). Pim-1S has been shown to localize predominantly in the nucleus (PMID:16186805).
- 基因简介:The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons (PMIDs:16186805, 1825810).[provided by RefSeq, Aug 2011]
- 规格:10ul 质粒
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