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- accession：NM_001145829
- 基因别名：TNNI2
- 基因描述：Homo sapiens troponin I type 2 (skeletal, fast) (TNNI2), transcript variant 2, mRNA.
- 载体：现货载体
- CDS区长度：549
- 翻译后氨基酸长度：182
- TranscriptVariant：This variant (2) has an alternate 5' UTR exon, and encodes the same isoform 1, as compared to variant 1.
- 基因简介：This gene encodes a fast-twitch skeletal muscle protein, a member of the troponin I gene family, and a component of the troponin complex including troponin T, troponin C and troponin I subunits. The troponin complex, along with tropomyosin, is responsible for the calcium-dependent regulation of striated muscle contraction. Mouse studies show that this component is also present in vascular smooth muscle and may play a role in regulation of smooth muscle function. In addition to muscle tissues, this protein is found in corneal epithelium, cartilage where it is an inhibitor of angiogenesis to inhibit tumor growth and metastasis, and mammary gland where it functions as a co-activator of estrogen receptor-related receptor alpha. This protein also suppresses tumor growth in human ovarian carcinoma. Mutations in this gene cause myopathy and distal arthrogryposis type 2B. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]
- 规格：10ul 质粒
CDS区参考序列： 点击查看序列翻译后氨基酸参数序列： 点击查看序列
