- accession:NM_024539
- 基因别名:RNF128
- 基因描述:Homo sapiens ring finger protein 128, E3 ubiquitin protein ligase (RNF128), transcript variant 2, mRNA.
- 载体:现货载体
- CDS区长度:1209
- 翻译后氨基酸长度:402
- TranscriptVariant:This variant (2) has an alternate 5' end exon compared to variant 1. The resulting isoform (2) has a distinct and shorter N-terminus, as compared to isoform 1.
- 基因简介:The protein encoded by this gene is a type I transmembrane protein that localizes to the endocytic pathway. This protein contains a RING zinc-finger motif and has been shown to possess E3 ubiquitin ligase activity. Expression of this gene in retrovirally transduced T cell hybridoma significantly inhibits activation-induced IL2 and IL4 cytokine production. Induced expression of this gene was observed in anergic CD4(+) T cells, which suggested a role in the induction of anergic phenotype. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
- 规格:10ul 质粒
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