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- accession：NM_138980
- 基因别名：MAPK10
- 基因描述：Homo sapiens mitogen-activated protein kinase 10 (MAPK10), transcript variant 3, mRNA.
- 载体：现货载体
- CDS区长度：1281
- 翻译后氨基酸长度：426
- TranscriptVariant：This variant (3) is also known as stress activated protein kinase beta. It contains a different 5' UTR region, and has an extra segment within the coding region, when compared to variant 2. The extra segment introduces an in-frame stop codon, so translation begins downstream, resulting in an N-terminal truncated isoform (3), as compared to isoform 2.
- 基因简介：The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
- 规格：10ul 质粒
CDS区参考序列： 点击查看序列翻译后氨基酸参数序列： 点击查看序列
