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- accession：NM_000389
- 基因别名：CDKN1A
- 基因描述：Homo sapiens cyclin-dependent kinase inhibitor 1A (p21， Cip1) (CDKN1A)， transcript variant 1， mRNA.
- 载体： pcDNA3.1-3xFlag-C
- CDS区长度：495
- 翻译后氨基酸长度：164
- TranscriptVariant：This variant (1) and variants 2， 4 and 5 encode the same protein.
- 基因简介：This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes， and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53， through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA)， a DNA polymerase accessory factor， and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases， which thus leads to a dramatic activation of CDK2， and may be instrumental in the execution of apoptosis following caspase activation. Multiple alternatively spliced variants have been found for this gene. [provided by RefSeq， Nov 2010]
- 载体信息：自有图片地址
- 规格：10ul 质粒
CDS区参考序列： 点击查看序列翻译后氨基酸参数序列： 点击查看序列
