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- accession：NM_001005409
- 基因别名：SF3A1
- 基因描述：Homo sapiens splicing factor 3a, subunit 1, 120kDa (SF3A1), transcript variant 2, mRNA.
- 载体：现货载体
- CDS区长度：2187
- 翻译后氨基酸长度：728
- TranscriptVariant：Transcript variant 2 uses two alternative splice sites in the coding region, compared to transcript variant 1. Variant 2 encodes isoform 2, which is shorter than isoform 1.
- 基因简介：This gene encodes subunit 1 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 1 belongs to the SURP protein family; named for the SURP (also called SWAP or Suppressor-of-White-APricot) motifs that are thought to mediate RNA binding. Subunit 1 has tandemly repeated SURP motifs in its amino-terminal half while its carboxy-terminal half contains a proline-rich region and a ubiquitin-like domain. Binding studies with truncated subunit 1 derivatives demonstrated that the two SURP motifs are necessary for binding to subunit 3 while contacts with subunit 2 may occur through sequences carboxy-terminal to the SURP motifs. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
- 规格：10ul 质粒
CDS区参考序列： 点击查看序列翻译后氨基酸参数序列： 点击查看序列
